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TitleAdvances in Swine in Biomedical Research [electronic resource] : Volume 2 / edited by Mike E. Tumbleson, Lawrence B. Schook
ImprintBoston, MA : Springer US : Imprint: Springer, 1996
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Descript XVIII, 483 p. online resource


Similarities in structure and function between pigs and human beings include size, feeding patterns, digestive physiology, dietary habits, kidney structure and function, pulmoยญ nary vascular bed structure, coronary artery distribution, propensity to obesity, respiratory rates, tidal volumes and social behaviors. Since the pig is an omnivore, it provides an adaptable model to evaluate chronic and acute exposures to xenobiotics such as alcohoL caffeine, tobacco, food additives and environmental pollutants. Swine have been used successfully as models to evaluate alcoholism, diabetes, absorption, digestion, total parenยญ teral nutrition, organ transplantation, atherosclerosis, exercise, hypertension. hemorrhagic hypotension, melanoma, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal healing and septic shock. A severe and worsening shortage of organs and tissues for transplantation in patients with severe organ failure has encouraged the consideration of inter species or xenotransplanยญ tation. In developing programs toward this end, the pig generally is viewed as the preferred donor because of its size, physiology and availability. The pig harbors relatively few diseases which could be transmitted inadvertently to human patients. The ability to genetically modify swine to ameliorate the consequences of the human immune response offers a further significant advantage. Another important consideration for an animal model is that basic biologic backยญ ground information be available for investigators to design future prospective studies


Methods and Techniques -- 37. Swine Research Breeds, Methods, and Biomedical Models -- 38. The Pig as a Model for Cutaneous Pharmacology and Toxicology Research -- 39. An in vitro Pig Skin Model for Predicting Human Skin Penetration and Irritation Potential -- 40. Swine Liver Usage in Extracorporeal Detoxification -- 41. Pig Behavior and Biomedical Research: Suitable Subjects and Experimental Models -- 42. Current Status of in vitro Production of Porcine Embryos -- 43. Reproductive Physiology in Chinese Meishan Pigs: A University of Illinois Perspective -- 44. Selection for Extremes in Serum FSH Concentrations Results in Reduced Testis Size and Fertility in Meishan and White Composite Boars -- 45. Reproductive Characteristics in Sinclair Miniature Swine -- 46. A Comparison of Physiological and Biochemical Parameters in Fully Conscious Hormel-Hanford and Yucatan Strains of Miniature Pig -- 47. Biochemical Indices of Stress Associated with Short-Term Restraint in Hormel and Yucatan Miniature Swine -- 48. The Minipig as a Model for the Study of Aging in Humans: Selective Responses of Hormones Involved in Carbohydrate and Lipid Metabolism in Different Sexes -- 49. Aging and Miniature Swine Heart and Liver Plasma Membranes -- 50. Comparing Porcine Models of Coronary Restenosis -- 51. Sinclair Miniature Swine Melanoma as a Model for Evaluating Novel Lymphography Contrast Agents -- 52. The Yucatan Miniature Pig Model of Ventricular Septal Defect -- 53. An External Thoracic Duct Venous Shunt to Allow for Long Term Collection of Lymph and Blood in the Conscious Pig -- 54. Pregnant Yucatan Miniature Swine as a Model for Investigating Fetal Drug Therapy -- 55. A Swine Model for Determining the Bioavailability of Lead From Contaminated Media -- 56. Evaluation of Sinclair Miniature Swine as an Osteopenia Model -- 57. Neovascularization of the Ischemic Myocardium by Cardiomyoplasty: Its Study Using the Casting Method and Selective Acute Myocardial Infarction in Swine -- 58. Vaccination Study with the Sinclair Miniature Swine-Effect of Vaccine Dose and Litter -- 59. Early Characterization of Panepinto Micro/Miniature Swine for Use as Transgenic Animal Models -- 60. Miniature Swine Breeds Used Worldwide in Research -- 61. The Siberian Miniature Pig, Its Development, Genetics, and Use in Biomedical Research -- Nutrition -- 62. Pigs as Models for Nutrient Functional Interaction -- 63. A Piglet Model for Neonatal Amino Acid Metabolism during Total Parenteral Nutrition -- 64. The Neonatal Piglet as a Model to Study Insulin Like Growth Factor Mediated Intestinal Growth and Function -- 65. The Perinatal Pig in Pediatric Gastroenterology -- 66. Prenatal and Perinatal Development of Intestinal Transport and Brush Border Hydrolases in Pigs -- 67. Changes in Pig Intestinal Structure and Functions and Resident Microbiota Induced by Acute Secretory Diarrhea -- 68. Helicobacter Pylori Infection in Gnotobiotic Piglets: A Model of Human Gastric Bacterial Disease -- 69. An Experimental Rotaviral Enteritis Model with Neonatal Pigs -- 70. Influence of Dietary Protein and Fat Sources on the Levels of Blood Homocysteine in a Pig Model: Preliminary Observations -- 71. Lung Eicosanoid Production in Neonatal Pigs Fed Formula Supplemented with N-3 and N-6 Fatty Acids -- 72. Genetically Diverse Pig Models in Nutrition Research Related to Lipoprotein and Cholesterol Metabolism -- 73. Glucose and Fatty Acid Metabolism in the Newborn Pig -- Author Index

Medicine Human genetics Pharmacology Nutrition Infectious diseases Animal physiology Biophysics Biological physics Medicine & Public Health Infectious Diseases Nutrition Pharmacology/Toxicology Human Genetics Animal Physiology Biophysics and Biological Physics


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