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TitleHomocysteine Metabolism: From Basic Science to Clinical Medicine [electronic resource] / edited by Ian Graham, Helga Refsum, Irwin H. Rosenberg, Per Magne Ueland, Jill M. Shuman
ImprintBoston, MA : Springer US : Imprint: Springer, 1997
Connect tohttp://dx.doi.org/10.1007/978-1-4615-5771-5
Descript XIV, 279 p. online resource

CONTENT

I. Biochemistry And Genetic Studies -- 1. The Regulation of Homocysteine Metabolism -- 2. Methionine Kinetics and Balance -- 3. On the Formation and Fate of Total Plasma Homocysteine -- 4. Methylenetetrahydrofolate Reductase: Comparison of the Enzyme from Mammalian and Bacterial Sources -- 5. Genetics of Mammalian 5,10-methylenetetrahydrofolate Reductase -- 6. Thermolabile Methylenetetrahydrofolate Reductase -- 7. The Long-term Outcome in Homocystinuria -- 8. Characterization of the Human and Porcine Methionine Synthases and their Redox Partners -- 9. Inherited Disorders of Folate and Cobalamin -- 10. Molecular Genetics of Cystathionine ?-Synthase in Homocystinuria and Vascular Disease -- 11. Cystathionine ?-synthase Deficiency: Metabolic Aspects -- II. Vitamins, Pathology, And Drug Therapy -- 12. Homocysteine and Other Metabolites in the Diagnosis and Follow-up of Cobalamin and Folate Deficencies -- 13. Vitamin Status and Hyperhomocysteinemia in a Healthy Population -- 14. Association Between Plasma Homocysteine, Vitamin Status, and Extracranial Carotid-Artery Stenosis in the Framingham Study Population -- 15. Treatment of Mild Hyperhomocysteinemia -- 16. Folate, Vitamin B12, and Neuropsychiatric Disorders -- 17. Vitamins, Homocysteine, and Neural-Tube Defects -- 18. The Etiology of Neural Tube Defects -- 19. Plasma Homocysteine in Renal Failure, Diabetes Mellitus, and Alcoholism -- 20. Homocysteine and Drug Therapy -- III. Homocysteine, Cancer, And Cardiovascular Disease -- 21. Is Methionine Useful for the Prevention of Hyperhomocysteinemia-Associated Cardiovascular Disease? -- 22. Synthesis of Homocysteine Thiolactone in Normal and Malignant Cells -- 23. Folate Status: Modulation of Colorectal Carcinogenesis -- 24. The Hordaland Homocysteine Study: Lifestyle and Total Plasma Homocysteine in Western Norway -- 25. Blood Homocysteine Levels in the National Health and Nutrition Examination Survey (NHANES III) in the United States: Preliminary Findings by Age and Sex -- 26. Heritability of Plasma Homocysteine Concentration -- 27. Plasma Homocysteine and Coronary Artery Disease -- 28. Homocysteine and Cerebral and Peripheral Vascular Disease -- 29. Plasma Homocysteine and its Relationship to Cardiovascular Risk Factors in a Japanese Population -- 30. Biological Chemistry of Thiols in the Vasculature and in Vascular-Related Disease -- IV. Intervention Studies and Concepts for the Future -- 31. Homocysteine and Vascular Disease: The European Concerted Action Project -- 32. Prospective Studies of Homocysteine and Vascular Disaese -- 33. A Meta-Analysis of Plasma Homocysteine as a Risk Factor for Arteriosclerotic Vascular Disease and the Potential Preventive Role of Folic Acid -- 34. Pathology of Homocystinuria -- 35. Lipoprotein(a), Homocysteine, and Atherogenesis -- 36. Endothelial- and Leukocyte-Mediated Mechanisms in Homocysteine-Associated Occlusive Vascular Disease


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