Title | Regulatory Mechanisms in Breast Cancer [electronic resource] : Advances in Cellular and Molecular Biology of Breast Cancer / edited by Marc E. Lippman, Robert B. Dickson |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1991 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-3940-7 |
Descript | IV, 452 p. online resource |
I. Oncogenes, antioncogenes, and tumor prognosis -- 1. Oncogenes as clinical prognostic indicators -- 2. Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma -- II. Growth factors and their receptors -- 3. Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland -- 4. Local effects of growth factors -- 5. The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer -- 6. The role of ras gene expression and transforming growth factor ? production in the etiology and progression of rodent and human breast cancer -- 7. The role of epidermal growth factor receptors in breast cancer -- 8. Cell proliferation in metazoans: Negative control mechanisms -- III. Estrogen and antiestrogens -- 9. Steroid modulation of the expression of growth factors and oncogenes in breast cancer -- 10. Antiestrogen therapy for breast cancer: Current strategies and potential causes for therapeutic failure -- 11. Steroidal pure antiestrogens -- 12. Estrogen-regulated messenger RNAs in human breast cancer cells -- 13. Estrogen and progesterone receptors -- 14. Growth factors as mediators of estrogen/antiestrogen action in human breast cancer cells -- 15. Steroids, growth factors, and cell cycle controls in breast cancer -- IV. Stromal-epithelial interactions and metastases -- 16. Stromal regulation of epithelial function -- 17. Mammary epithelial cells, extracellular matrix, and gene expression -- 18. Tenascin in mammary gland development: From embryogenesis to carcinogenesis -- 19. Stromal-epithelial interactions in normal and neoplastic mammary gland -- 20. Extracellular matrix metalloproteinases in tumor invasion and metastasis