Title | Coagulation and Blood Transfusion [electronic resource] : Proceedings of the Fifteenth Annual Symposium on Blood Transfusion, Groningen 1990, organized by the Red Cross Blood Bank Groningen-Drenthe / edited by C. Th. Smit Sibinga, P. C. Das, P. M. Mannucci |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1991 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-3900-1 |
Descript | XIV, 270 p. online resource |
I. Principles and fundamentals -- The mechanisms of thrombin formation -- Structure-function relationships of human coagulation proteins -- The role of calcium in coagulation and anticoagulation -- Effect of blood collection on the hemostatic potential of coagulation proteins -- Factor VIII yields from anticoagulant exchanged Haemonetics Ultraliteโข plasma -- Discussion -- II.Preservation aspects -- Platelet function preservation -- Platelet adhesion to the vessel wall -- Trends in the production and use of coagulation factor concentrates -- Immunoaffinity purification of Factor VIII/von Willebrand factor complex -- Structural and functional properties of recombinant coagulation factors -- Discussion -- III. Laboratory Aspects -- Platelet counting and function testing -- Selection of platelet apheresis donors for alloimmunized patients by ELISA platelet crossmatch versus HLA-matching -- Clinical efficacy of platelet concentrates -- Principles of coagulation factor assays -- Standardization of clotting factor assays -- Protein C and S in swiss blood donors -- Clinical efficacy of clotting factor concentrates: survival, recovery and hemostatic capacity -- Discussion -- IV. Clinical consequences -- Principles in the treatment of bleeding -- The effect of chronic exposure to clotting factor concentrates on the immune system -- Liver transplantation and blood usage -- The use of aprotinin in cardiopulmonary bypass and the impact on hemostasis and blood transfusion -- Discussion