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TitleTriazenes [electronic resource] : Chemical, Biological, and Clinical Aspects / edited by Tullio Giraldi, Thomas A. Connors, Giuseppe Cartei
ImprintBoston, MA : Springer US : Imprint: Springer, 1990
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Descript VIII, 227 p. online resource


Triazenes: Synthesis and Chemical Properties -- Mechanisms of the Biological Actions of Triazenes -- Triazenes and Triazene N-Oxides: Antitumour Action in Animal Tumour Systems -- Antimestastatic Action of Triazene Derivatives -- Effects of Triazenes on Immune Responses -- Xenogenization of Experimental Tumors by Triazene Derivatives -- The Metabolism of Antineoplastic Triazenes -- Notes on the Metabolism, Pharmacokinetics and Mode of Action of N-Methyl and N-Ethyl-Triazenes in Relation to Their Pharmacological Activity -- Clinical Use of Triazenes -- Clinical Studies with the p-Carboxyl-Dimethyl-Phenyl-Triazene CB10โ{128}{147}277 -- Triazenes: Therapeutic Considerations and Perspectives -- Antitumor Imidazotetrazines: Prodrugs Targeted to the Major Groove of DNA -- O6-Alkylguanine-DNA-Alkyltransferase Gene Expression and the Cytotoxicity of Triazenes -- N-Methylmelamines, a Unique Class of Anti-Tumour Agents? -- Experimental Background and Early Clinical Studies with Imidazotetrazine Derivatives -- โ{128}{152}O6-Alkylguanine-DNA-Alkyltransferase: Significance, Methods of Measurement and Some Human Tumor and Normal Tissue Levelsโ{128}{153} (Contributions of the Workshop) -- Summary of Poster-Sessions -- Contributors

Medicine Cancer research Oncology Biochemistry Medicine & Public Health Oncology Cancer Research Biochemistry general


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