Title | Recombinant Technology in Hemostasis and Thrombosis [electronic resource] / edited by Leon W. Hoyer, William N. Drohan |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1991 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-3698-7 |
Descript | VIII, 261 p. online resource |
Characterization of Gene and Protein Structure -- Biosynthesis and Assembly of the Factor VIII-von Willebrand Factor Complex -- Factor IX: Gene Structure and Protein Synthesis -- Antithrombin III Genetics, Structure and Function -- Interactions Between the Functional Domains of Antithrombin III -- Protein C: Gene Structure and Protein Synthesis -- Structural and Functional Properties of Protein C -- Molecular Defects Affecting Hemostasis -- Molecular Defects in Hemophilia A -- Molecular Defects in Hemophilia B -- Molecular Defects in Human Antithrombin III Deficiency -- The Biologic Impact of Hereditary Defects that Cause Thrombosis -- Protein Production by Recombinant Technology -- Factors Limiting Expression of Secreted Proteins in Mammalian Cells -- Synthesis of Biologically Active Vitamin K-Dependent Coagulation Factors -- The Expression of Therapeutic Proteins in Transgenic Animals -- Clinical use of Proteins Produced by Recombinant Technology -- The Use of Animal Models to Evaluate Proteins Produced by Recombinant Technology -- Experiences with Recombinant Factor VIIa in Hemophiliacs -- Clinical Trials of Factor VIII Produced by Recombinant Technology -- Clinical Trials of Recombinant Factor VIII -- Concluding Overview -- The Impact of Recombinant Technologies in Understanding Plasma Proteins Important for Hemostasis and Thrombosis -- Contributors