Title | Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development [electronic resource] : Proceedings of the Twenty-Second Annual Cancer Symposium Detroit, Michigan, USA โ April 26-28, 1990 / edited by Frederick A. Valeriote, Thomas H. Corbett, Laurence H. Baker |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1992 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-3492-1 |
Descript | XVII, 409 p. online resource |
1. DRUG DISCOVERYโ 1990 -- 2. DATA DISPLAY AND ANALYSIS STRATEGIES FOR THE NCI DISEASE-ORIENTED IN VITRO ANTITUMOR DRUG SCREEN -- 3. DISCOVERY OF SOLID TUMOR ACTIVE AGENTS USING A SOFT-AGAR-COLONY-FORMATION DISK-DIFFUSION- ASSAY -- 4. THYMIDYLATE SYNTHASE INHIBITION OF MODIFIED QUINAZOLINE ANTIFOLATES -- 5. DNA-MINOR GROOVE BINDING ANTICANCER AGENTS -- 6. 2-((ARYLMETHYL)AMIN0)-l,3-PR0PANEDI0LS (AMAPS); DISCOVERY, SELECTION AND DEVELOPMENT OF FOUR CLINICAL CANDIDATES -- 7. MECHANISM-BASED APPROACHES TO CANCER DRUG DISCOVERY -- 8. DISCOVERY AND BULK PRODUCTION OF NATURAL PRODUCTS WITH ANTICANCER ACTIVITY: THE ROLE OF CHEMICAL ECOLOGY -- 9. CHEMICAL APPROACHES TO IMPROVED RADIOTHERAPY -- 10. LARGE SCALE ANTICANCER DRUG SCREENING AT STERLING DRUG INC. -- 11. ARE ANTISENSE OLIG0NUCLEOTIDES THERAPEUTIC AGENTS OF THE FUTURE? -- 12. SUPERCOMPUTER AIDED DRUG DESIGN: APPLICATION IN ONCOLOGY AND AIDS -- 13. EXTRACHROMOSOMAL DNA AS A TARGET FOR DRUG DEVELOPMENT -- 14. PROSPECTIVE EVALUATION OF A PREDICTIVE MODEL FOR PLASMA CONCENTRATION-VERSUS-TIME PROFILES OF INVESTIGATIONAL ANTICANCER DRUGS IN PATIENTS -- 15. AGENT-DIRECTED PRECLINICAL TOXICOLOGY FOR NEW ANTINFOPLASTIC DRUGS -- 16. PRECLINICAL STUDIES WITH BREQUINAR SODIUM: A NOVEL ANTICANCER AGENT -- 17. DIPHTHERIA TOXIN-RELATED PEPTIDE HORMONE FUSION PROTEINS: NEW TOXINS WITH THERAPEUTIC POTENTIAL -- 18. ANTI-GROWTH FACTOR RECEPTOR ANTIBODIES AS THERAPY FOR CANCER -- 19. REGULATION OF POLYAMINE BIOSYNTHETIC ACTIVITY AND HOMEOSTASIS AS A NOVEL ANTIPROLIFERATIVE STRATEGY -- 20. ESPERAMICIN A1 (BMY28175)- A NOVEL ANTI- TUMOR AGENT OF THE DIYNE-ENE CLASS -- 21. MODIFIED 2-TUMOR (L1210, COLON 38) ASSAY TO SCREEN FOR SOLID TUMOR SELECTIVE AGENTS -- 22. 5-FLUOROURACIL: SCHEDULE OPTIMIZATION IN METASTATIC COLORECTAL CANCER -- 23. PRECLINICAL ANTITUMOR EFFICACY OF TAXOTERE (RP56976, NSC 628503), A TAXOL ANALOG AND OF RP60475 (NSC645008), A NEW BENZOPYRI- DOINDOLE