Title | Treatment of Dementias [electronic resource] : A New Generation of Progress / edited by Edwin M. Meyer, James W. Simpkins, Jyunji Yamamoto, Fulton T. Crews |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1992 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-3432-7 |
Descript | 448 p. 31 illus. online resource |
Section I. Cholinergic Drugs in Alzheimerโs Treatment -- Muscarinic Receptors:Molecular Biology and Neuropsychopharmacology -- Cholinomimetic Replacement of Cholinergic Function in Alzheimer Disease -- The Muscarinic Modulation of Acetylcholine Release from the Rat:Nostriatum Changes with Senescence -- Effects of Cholinergic Agents and Basal Forebrain Lesions in Rabbits -- Differential Effect of Aging on Hippocampal Pyramidal Cell Responses to Muscarine and Nicotine -- Modulation of Learning and Memory via Benzodiazepine Receptors:Potential Treatments for Age-related Dementia -- Acetylcholine-somatostatin Interactions:Potential Implications for the Treatment of Alzheimerโs Disease -- Section II. Growth Factors in Alzheimerโs Treatment -- The Role of Neurotrophins in the Central Nervous System:Significance for the Treatment of Neurodegenerative Diseases -- Contrasting Effects of Specific Lymphokines on the Survival of Hippocampal Neurons in Culture -- Growth Factor Regulation of Brain Protease Inhibitors -- Regulation of the Choline Acetyltransferase Gene -- Recombinant Human Nerve Growth Factor Increases Presynaptic Cholinergic Function Following Neuronal Damage:Implications for the Treatment of Alzheimerโs Disease -- Delayed Neuronal Death of Hippocampus (CA1) after Transient Global Ischemia:Does Nerve Growth Factor Protect Neurons Against โKiller Proteins?โ -- Seizure-dependent Regulation of BDNF mRNA in the Rat Brain -- Section III. Phospholipids in Alzheimerโs Treatment -- Phosphatidylserine Stimulation of Macrophage Protein Secretion:Potential Healing and Trophic Mechanisms -- Pharmacological Effects of Phosphatidylserine in the Aging Rat Brain -- Effects of Phosphatidylserine in Age-associated Memory Impairment and Alzheimerโs Disease -- Section IV. Ion Channel Modulators in Alzheimerโs Disease -- Nimodipine Improves Learning and Sensorimotor Behaviors in Aging Mammals -- Cellular Mechanisms for Nimodipineโs Reduction of Aging-related Learning Deficits -- Selective Alterations in n-methyl-d-aspartate Receptor Coupled. Responses with Aging:Implications for Therapy -- Modulation of Frontal Cortical Acetylcholine Release by Benzodiazepine Receptor Ligands:Age-dependent Effects and Behavioral Correlates -- Section V. CNS Targeted Drug Delivery -- Enhanced Brain Delivery of Amino Acids and Peptides Through the Use of Redox Trageting Systems -- Brain Targeted Delivery of Neurotransmitters:Use of a Redox Based Chemical Delivery Stystem -- Procedures for Penetrating the Blood-brain-barrier:Studies of g-aminobutyric Acic (GABA) -- Sendai Virosome Envelopes for the Infusion of Macromolecules into Brain Neurons and Glia -- Section VI. Normal Aging -- Oxidative Stress and the Loss of Muscarinic and Dopaminergic Responsiveness in Senescence -- Unique Aspects of Muscarinic Receptor Stimulated Inositol Polyphosphate Formation in Brain:Changes in Senescence -- Role of Aluminum and Iron in Brain Disorders -- RNA Metabolism in Human Brain During Aging and in Alzheimerโs Disease:RNA Synthesis in the Nuclei Isolated from Postmortem Brain Tissue -- Regulation of Glutamate Release in Aging -- Potential Therapeutic Use of Growth Hormone in the Metabolic Treatment of Alzheimerโs Disease -- Disturbed Body Weight Control in Geriatric Rats:A Model for Anorexia in Alzheimerโs -- Section VII. Animal Models for Alzheimerโs Disease -- Cholinergic Phenotype of Septal Cell Lines -- Selective Death of Cholinergic Septohippocampal Neurons Induced by Colchicine:The Role of Axoplasmic Transport -- Inhibition of Cytochrome Oxidase Impairs Learning and Hippocampal Plasticity:A Novel Animal Model of Alzheimerโs Disease -- ร-Amyloid Peptides, Aluminum and Albumin -- Transmission Study of Neurofilament Pathology in Hamster Brain Produced by Alzheimer Buffy Coat Inoculation