Title | Boron Neutron Capture Therapy [electronic resource] : Toward Clinical Trials of Glioma Treatment / edited by Detlef Gabel, Ray Moss |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1992 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-3408-2 |
Descript | IX, 279 p. online resource |
Opening Speech -- Welcome Address -- Safety and Efficacy in Boron Neutron Capture Therapy -- Some Aspects of BNCT Research at the BrookhavenNational Laboratory -- INEL BNCT Program Directions with Respect to Clinical Trials of BNCT -- The Department of Energy Research Program in Boron Neutron Capture Therapy -- Current Overview on the Approach of Clinical Trials at Petten -- Review of the Physics Calculations Performed for the BNCT Facility at the HFR Petten -- From Filter Installation to Beam Characterization -- Neutron Spectrometry Measurements of the Petten HFR, HB11 Neutron Beam -- A Semi-Empirical Method of Treatment Planning for Boron Neutron Capture Therapy -- Present Status of the Three-Dimensional Treatment Planning Methodologies for the Petten BNCT Facility -- A Phase 1 Biodistribution Study of P-Boronophenylalanine -- RBE in Normal Tissue Studies -- Treatment Planning and Optimization for Pion Therapy -- Dose Calculations Based on Image Reconstructions -- Borocaptate Sodium (BSH) Pharmacokinetics in Glioma Patients -- BSH in Patients with Malignant Glioma: Distribution in Tissues, Comparison Between BSH Concentration and Histology -- Macroscopic and Microscopic Biodistribution of Bsh in a Rat Glioma Model -- Healthy Tissue Tolerance Studies for BNCT at the High Flux Reactor in Petten - First Results -- Cellular Pharmacokinetics of BNCT Compounds and their Cellular Localization with EELS/ESI -- Large Animal Model Studies of Normal Tissue Tolerance Using an Epithermal Neutron Beam and Borocaptate Sodium -- Proposal for Patient Selection Criteria and Follow-Up for BNCT in Patients with Supratentorial Malignant Gliomas -- A Proposal for Phase I Clinical Trials of Glioma Patients -- Approaches to the Design and Evaluation of Compounds for BNCT -- The Implementation Strategy for BNCT Trials in Australia -- Round Table Discussion Approach to Clinical Trials of Glioma -- Author Index -- Participants