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TitleDiastolic Relaxation of the Heart [electronic resource] : The Biology of Diastole in Health and Disease / edited by Beverly H. Lorell, William Grossman
ImprintBoston, MA : Springer US : Imprint: Springer, 1994
Edition Second Edition
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Descript XIII, 348 p. online resource


Numerous studies have documented the importance of diastolic dysfunction in heart disease. Now, providing cardiologists with the most current information available on the subject, the editors have pulled together contributions from an impressive array of top researchers and compiled them into one comprehensive, carefully edited source, Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease. This brand new Second Edition, based on a recent meeting, includes such topics as: molecular biology of relaxation; consequences of altered gene expression; impaired relaxation in experimental models (ischemia and hypoxia, and hypertrophy and failure); diastolic dysfunction in the diseased human heart. Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease, the successor to the editors' bestselling work on the same subject, published in 1987 - belongs on the shelf of every practising cardiologist. It will also be an invaluable addition to the library of scientists researching the effects of diastole on heart function


I. Molecular Biology of Relaxation -- 1. Overview: The Molecular Phenotype of Normal and Impaired Relaxation -- 2. Regulation of Gene Expression in the Failing Myocardium: Evidence for a Heart Failure Gene Program -- 3. Sarcoplasmic Reticulum Gene Expression in Human Heart Failure -- 4. Molecular Aspects of the Control of Myocardial Relaxation -- 5. Molecular Physiology of Ventricular Hypertrophy -- II. Consequences of Altered Gene Expression: The Economy of Diastole -- 6. Regulatory Proteins and Diastolic Relaxation -- 7. Intracellular Free Calcium in Hypertrophy and Failure -- 8. A Molecular Biophysical Approach to Contraction and Relaxation -- 9. On the Relations Among ATP Hydrolysis, Cation Accumulation, and Diastolic Dysfunction -- 10. Adrenergic Signal Transduction in Congestive Heart Failure: Effects on Diastole -- 11. Cardiac Renin-Angiotensin System in Cardiac Hypertrophy and Failure -- 12. Altered Force-Frequency Relation and Excitation-Contraction Coupling in the Failing Human Heart. Relevance of SR-Ca2+-ATPase Protein Levels -- III. Impaired Relaxation in Experimental Models: Ischemia and Hypoxia -- 13. Effects of Hypoxia and Ischemia on Intracellular Calcium and Relaxation: Studies in the Aequorin-Loaded Whole Heart Model -- 14. Diastolic Dysfunction During Ischemia: Role of Glycolytic ATP Generation -- 15. Does Calcium Overload Adequately Explain Diastolic Dysfunction during Metabolic Inhibition? -- 16. Mechanisms of Relaxation: Perspectives from Studies in Single Cardiac Cells -- 17. Modulation of Diastolic Dysfunction in the Intact Heart -- 18. Altered Load: An Important Component of Impaired Diastolic Function in Hypertension and Heart Failure -- 19. Endothelial-Ventricular Interaction in Normal and Diseased Hearts -- IV. Impaired Relaxation in Experimental Models: Hypertrophy and Failure -- 20. Diastolic Dysfunction in Experimental Heart Failure -- 21. Interplay of Hypertrophy and Myocardial Ischemia -- 22. Myocardial Fibrosis: Structural Basis for Diastolic Dysfunction -- 23. Coronary Venous Pressure and Left Ventricular Diastolic Distensibility -- 24. Pericardium and Ventricular Interaction: Effects on Diastolic Filling -- 25. Diastolic Dysfunction in Tachycardia- Induced Heart Failure -- 26. Diastolic Abnormalities in Low-Flow and Pacing Tachycardia-Induced Ischemia in Isolated Rat Hearts โ{128}{148} Modification by Calcium Antagonists -- V. Diastolic Dysfunction in The Diseased Human Heart -- 27. Diastolic Dysfunction and Myocardial Energetics -- 28. Diastolic Dysfunction in Chronic Pressure and Volume Overload -- 29. Sustained Diastolic Dysfunction Following Severe Exercise-Induced Ischemia in Patients with Coronary Disease -- 30. Exercise Intolerance in Patients with Heart Failure: Role of Diastolic Dysfunction -- 31. Comparative Effects of Ischemia and Hypoxemia on Left Ventricular Diastolic Function in Humans -- 32. Determinants of Left Ventricular Diastolic Filling: Insights from Echo-Doppler

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