I. Blood Coagulation -- The Molecular Biology of Haemophilia -- Molecular Biology of the Various Types of Von Willebrand Disease -- Molecular Basis of Thrombophilia -- Inhibitory Sequences Within the Clotting Factor VIII cDNA Block Transcriptional Elongation and Complicate Efforts Toward Gene Therapy for Haemophilia A -- II. Haemoglobin and Red Cells -- Globin Gene Regulation -- Molecular Pathology of the Thalassaemia Syndromes -- The Current Status of Bone Marrow Transplantation and Gene Therapy in the Management of TheHaemoglobinopathies -- The Molecular Biology of Blood Groups: Relevance to the Study of Erythroid Maturation and the Clinical Management of Haemolytic Disease of the Newborn -- Genetic Abnormalities in Blood Group Serology -- III. White Cells and Malignancies -- The Role of The Blood Bank in Human Gene Therapy Trials -- Translocation in Cancer: Mechanism of Oncogenic Conversion and Implications for Therapy -- Role of Topoisomerase II A and B Isozymes in Determining Drug Resistance In Vitro and In Vivo -- Impact of Cell Culture Technology on Transfusion Medicine -- Gene Therapy for Primary Immune Deficiencies -- IV. Gene Technology, Ethics and the Future -- Ethics and Genetic Manipulation -- Is There a Role for Transfusion Medicine in the Genetic Correction of Genetic Disorders and Other Diseases? -- Vectors for Gene Therapy: Strategies for Making Gene Therapy Work -- From Blood Stain to Pathogenesis Study of Human Hereditary Diseases -- The Potential Impact of Gene Therapy in Blood Transfusion