I. Molecular and Cellular Biology of Adenosine and ATP -- A. Molecular Biology -- 1. Molecular Biology of Adenosine Receptors -- 2. Recombinant Techniques as Applied to the Study of A1Adenosine Receptors -- 3. In Situ Hybridization of Adenosine Receptors in Brain -- 4. Molecular Modeling of Adenosine A1and A2aReceptors -- 5. Purinoceptor Nomenclature: Challenges for the Future -- 6. Molecular Cloning and Expression of SNST1, a Renal Sodium/Nucleoside Cotransporter -- 7. Antibodies as Probes of Nitrobenzylthioinosine-Sensitive Nucleoside Transporters -- B. Cellular Biology -- 8. Regulation of the Human A1Adenosine Receptor Gene -- 9. Adenosine A2Receptor Regulation of Striatal Gene Expression -- 10. Neuronal ATP Receptors -- 11. Possible Role of Glia in the Induction of CNS-like Properties in Aortic Endothelial Cells: ATP-Activated Channels -- 12. Modulation of Cardiomyocyte Membrane Currents by A1Adenosine Receptors -- 13. Regulation of Phospholipases C and D, Calcium, and Protein Kinase C by Adenosine A1Receptors -- 14. Adenosine Derived from Neurally Released ATP Is the Physiologic Cause of Skeletal Neuromuscular Depression -- 15. Adenosine 5โ-Triphosphate ReceptorโMediated Currents in Rat Intracardiac Neurons -- 16. Desensitization of A1Adenosine Receptors -- II. Medicinal Chemistry -- 17. Selective A2Adenosine Receptor Agonists with Potent Inhibitory Activity on Platelet Aggregation -- 18. Novel ATP Agonists Reveal Receptor Heterogeneity within P2xand P2ySubtypes -- 19. Adenosine Receptors: Selective Agonists and Antagonists -- III. Purine Release and Metabolism -- 20. Cardiac Energetics and Adenosine Formation -- 21. Extracellular Hydrolysis of ATP and Formation of Adenosine in the Nervous System -- 22. P-Glycoprotein Serves as a Transporter of Cellular ATP -- 23. On the Origin of Extracellular ATP in Cardiac Blood Vessels: A Dual Role for Endothelium -- 24. Aliosteric Modulation of Nucleoside Transport by Adenosine and ATP -- IV. Physiology and Pharmacology of Adenosine and ATP: Effects on Tissue and Organs -- A. Renal System -- 25. Chloride Secretion in the Shark Rectal Gland: A Model for Epithelial Adenosine Receptors -- B. Cardiovascular System -- 26. Myocardial Adenosine Receptors -- 27. Coronary Adenosine Receptors: Subtypes, Localization, and Function -- 28. Biologic Activity of Adenosine A2aReceptor Antagonists -- C. Nervous System (Central and Peripheral) -- 29. Role of A2aReceptors in the Hippocampus and Motor Nerve Endings -- 30. Augmentation of Extracellular Adenosine Formation as a Potential Therapeutic Strategy for Preventing Excessive Excitatory Amino Acid Transmission in the Central Nervous System -- 31. Purinoceptors on Glial Cells of the Central Nervous System: Functional and Pathologic Implications -- 32. Inhibitory Action of Adenosine and Adenine Dinucleotides on Synaptic Transmission in the Central Nervous System -- 33. Receptors for ATP at Peripheral Neuroeffector Junctions -- 34. Anatomic-Functional Correlates of Adenosine-5โ-Triphosphate Triggered Vagal Depressor Reflex -- 35. Excitatory Effect of Adenosine on Cardiac Sympathetic Afferent Fibers -- 36. Mechanism of Anginal Pain: The Key Role of Adenosine -- D. Other Systems -- 37. The P2ZReceptor and its Regulation of Macrophage Function -- 38. Effects of Purinoceptor Agonists on Insulin Secretion -- V. Cytoprotective Actions of Adenosine -- A. Cardioprotection -- 39. Receptor-Mediated and Metabolic Effects of Adenosine in Ischemic and Postischemic Myocardium -- 40. Role of Activation of Ecto-5โ- Nucleotidase for Cardioprotection in Ischemic Preconditioning -- 41. Adenosine Uptake Blockers for Cardioprotection -- 42. Endothelial Adenosine Receptors Modulate Leukocyte Adhesion: Relevance for Myocardial Reperfusion Damage -- B. Neuroprotection -- 43. Adenosine and Brain Ischemia -- 44. Adenosine Metabolites Are a Source of Oxygen Free Radicals in the Ischemic/Reperfused Rat Brain -- 45. Hyperglycemic Ischemia and Reperfusion: Effects on Adenosine and Adenine Nucleotides -- C. Renal Protection -- 46. Studies on the Mechanism by Which Adenosine Receptor Antagonists Attenuate Acute Renal Failure -- VI. Therapeutic Applications -- A. Cardiovascular -- 47. Clinical Electrophysiology of Adenosine -- 48. Myocardial Imaging during Adenosine Infusion -- 49. Intravenous Adenosine and Lidocaine in the Limitation of Infarct Size: Preliminary Safety Data -- 50. Role of Adenosine in the Phenomenon of Ischemic Preconditioning -- B. Nervous System -- 51. Anticonvulsant Actions of Novel and Reference Adenosine Agonists -- 52. Behavioral Effects of Adenosine Receptor Stimulation -- 53. Evidence for the Existence of Antagonistic Intramembrane Adenosine A2a/Dopamine D2Receptor Interactions in the Basal Ganglia: Analysis from the Network to the Molecular Level -- C. Other Applications -- 54. Role of Adenosine and Adenosine Triphosphate as Anesthetic Adjuvants -- 55. Mechanisms and Therapeutic Actions of Uridine Triphosphate in the Lung

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