Title | Ocular Toxicology [electronic resource] / edited by Ingo Weisse, Otto Hockwin, Keith Green, Ramesh C. Tripathi |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1995 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-1887-7 |
Descript | X, 378 p. online resource |
Welcome and Opening of the Congress -- A. Ocular Electrophysiology -- The ERG, EOG, and VEP in rats -- Retinal toxicology study using electrophysiological methods in rabbits -- ERG measurements in the dog, cat and monkey for toxicology specially type of electrode and anesthesia for ERG recordings -- Electroretinography in the non-human primate as a standardized method in toxicology -- Effects of clindamycin on neural function in the isolated perfused vertebrate retina -- Determination of the effect of ketamine, thiopental and halothane on the ocular electroretinographic examination of the beagle dog to define protocols to be used in dogs, monkeys and micropigs -- Experimental study of the retinal toxicity of iron after vitreous hemorrhage -- Retinal tolerance of intravitreal low-molecular-weight heparin, colchicine or interferon ร determined by eye-cup ERG in albino rabbits -- Normal ERG on rhesus monkeys (Macaca mulatta): Preliminary results of a technic using subcutaneous electrodes -- Effects of quinine on the electroretinogram of the beagle dog -- B. Ocular Pharmacokinetics -- Effect of different vehicles on ocular kinetics/distribution -- Drug distribution studies in single lens layers through the application of a sectioning technique -- Ocular pharmacokinetics of some proteolytic drugs in the course of topical application: Long-term observation -- New method of the reverse intraarterial drug infusion into final periorbital channels of the ophthalmic artery in urgent treatment of toxic opticneuropathy -- Evaluation of the effect of the vehicle on ocular distribution and bioavailability of Betaxolol -- Continuous flow contact lens delivery of diclofenac to rabbit cornea and aqueous humor -- One-year ocular toxicity study of ofloxacin ophthalmic solution in beagle dogs -- Topical fluconazole: High penetration without corneal toxicity -- C. Lens/Cataract -- Relevance of cataract models in rodents as a tool to evidence a co- or syncataractogenic potential of drugs in preclinical studies -- Influence of PHAKANR on the lens toxicity of naphthalene in rat lenses, analyzed by isoelectric focusing of single lens layers -- Investigations into the cataractogenic potency of a non-tricyclic antidepressant -- Comparative investigations on the cataratogenic effect of a triazin-derivative in albino and pigmented rats: I. effects detected with a slit lamp -- Regionality of glycated calf lens crystallin subunits demonstrated by lectin staining -- Spatial distribution of adenosin nucleotides in lenses of species with different accommodative capacities -- Hyperbaric oxygen therapy induces a lenticular myopic shift even with shorter treatment protocol: A preliminary report -- Posterior subcapsular cataracts and raised intraocular pressure are caused by prolonged oral corticosteroid therapy in adutt patients with inflammatory bowel disease -- D. In Vitro Methods -- In vitro methods in ocular toxicology: Introductory remarks -- (3H)-arachidonic acid release as an alternative for the eye irritation test -- Cytotoxic effects of antifungal drugs on cultured human conjunctival cells -- Characterization of sialomucins expressed by human conjuctival goblet cells -- E. Regulatory Affairs -- Critical evaluation of the evidence for an association between ocular disease and exposure to organophosphorus compounds -- A practical testing strategy for the evaluation of the oculotoxic potential of chemicals -- F. Miscellaneous -- Aesthesiometry-azelastine eye drops reduce corneal sensitivity in rabbits, but not in dogs and humans -- Influence of chronic alcoholic intoxication on healing of corneal epithelial defects. Effectivity of treatment by protease inhibitor contrycal (aprotinin) and autologous fibronectin -- The use of cyclosporine A in veterinary ophthalmology -- Characterization of human tear glycoproteins by phast SDS electrophoresis, western blotting and lectin binding -- The corneal effects of 2-(2-nitro-4-trifluoromethyl-bencoyl)-cyclohexane 1,3 dione (NTBC) in the rat -- Exacerbation of spontaneous rat corneal opacities in a polymorphonuclear elastase inhibitor toxicity study -- The comet assay: A reliable and sensitive method for the documentation of UV-B induced DNA damage -- Spontaneous ocular findings and esthesiometry/tonometry measurement in the Gรถttingen minipig (conventional and microbiologically defined) -- Measurement of intraocular pressure in cynomolgus monkeys using a TonopenR -- Lead-intoxication of dopaminergic cells in the retina