Title | Molecular Basis of Pancreas Development and Function [electronic resource] / edited by Joel F. Habener, Mehboob A. Hussain |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 2001 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-1669-9 |
Descript | XIV, 412 p. online resource |
1. An Historical and Phylogenetic Perspective of Islet-Cell Development -- 2. Glucose Signalling to Transcription Factors of the Insulin Gene -- 3. ?-Cell Dysfunction and Chronic Hyperglycaemia -- 4. Glucose Toxicity of the Pancreatic ?-cell -- 5. The ?-Cell and Regulation of Glucagon Gene Transcription -- 6. The KATP Channel and the Sulfonylurea Receptor -- 7. Glucagon-Like Peptide-1: An Insulinotropic Hormone with Potent Growth Factor Actions at the Pancreatic Islets of Langerhan -- 8. Communication of Islet Cells: Molecules and Functions -- 9. Soluble Factors Important for Pancreas Development -- 10. Role of Mesenchymal-Epithelial Interactions in Pancreas Development -- 11. Homeodomain Proteins in Pancreas Development -- 12. bHLH Factors and Notch in Pancreatic Development -- 13. Identification, Biological Functions, and Contribution to Human Diabetes of Islet-Brain 1 -- 14. Pax4 and Pax6 in Islet Differentiation -- 15. The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis -- 16. Regulation of PDX-1 Gene Expression -- 17. Mechanisms of Postnatal ?-Cell Mass Regulation -- 18. Genetic Models of Insulin Resistance: Alterations in ?-Cell Biology -- 19. Clinical Consequences of Genetic Defects in ?-Cell Genes -- 20. Pathophysiology of Glut2 in Diabetes Mellitus -- 21. Use of a Cre-LoxP Strategy in Mice to Determine the Cell-Specific Roles of Glucokinase in MODY-2 -- 22. Development of ?-Cell Lines for Transplantation in Type 1 Diabetes Mellitus -- 23. Gene Therapeutic Approaches for ?-Cell Replacement -- Colour Figures