Office of Academic Resources
Chulalongkorn University
Chulalongkorn University

Home / Help

TitleClinically Relevant Resistance in Cancer Chemotherapy [electronic resource] / edited by Borje Andersson, David Murray
ImprintBoston, MA : Springer US : Imprint: Springer, 2002
Connect tohttp://dx.doi.org/10.1007/978-1-4615-1173-1
Descript XX, 380 p. online resource

SUMMARY

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased longยญ term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge


Medicine Cancer research Oncology Medicine & Public Health Oncology Cancer Research



Location



Office of Academic Resources, Chulalongkorn University, Phayathai Rd. Pathumwan Bangkok 10330 Thailand

Contact Us

Tel. 0-2218-2929,
0-2218-2927 (Library Service)
0-2218-2903 (Administrative Division)
Fax. 0-2215-3617, 0-2218-2907

Social Network

  line

facebook   instragram