1 PACAP: Discovery, Gene, Receptors -- 2 Molecular Evolution of PACAP Precursor and PACAP Receptors -- 3 Development of Selective Ligands for PACT, VPAC1 and VPAC2 Receptors -- 4 Molecular Pharmacology and Structure-Function Analysis of PACAP/VIP Receptors -- 5 PACAP Receptor Signaling -- 6 Function of PACAP in the Central Nervous System -- 7 Function of PACAP in the Hypothalamo-Pituitary Complex -- 8 PACAP in the Endocrine Pancreas -- 9 Function of PACAP in the Adrenal Cortex -- 10 PACAP: An โ{128}{152}Emergency Responseโ{128}{153} Co-Transmittter in the Adrenal Medulla -- 11 PACAP in the Urogenital Tract -- 12 Function of PACAP in the Cardiovascular System -- 13 Function of PACAP in the Respiratory System -- 14 Function of PACAP in the Immune System -- 15 PACAP Receptor Knockout and Transgenics. What Have We Learnt? -- 16 Consequences of PACAP Gene Knockout -- 17 The Biological Significance of PACAP and PACAP Receptors in Human Tumors: From Cell Lines to Cancers