This text is the written form of the proceedings of a satellite symposium associated with the 1988-meeting of the Society for Neuยญ roscience. The symposium was held 12 November 1988 in the auditorยญ ium of the Addictions Research Foundation, Toronto, Canada. The acยญ tual writing took place across the months following the symposium. The symposium was sponsored by the Addictions Research Foundation, Toronto, Canada, the National Institute on Alcohol Abuse and Alcoholism, U. S. A. , and Rensselaer, Troy, NY, U. S. A. Du Pont Pharmaceuticals provided some financial assistance. Contributors also received specific support for their own projects and these are acยญ knowledged at the end of each chapter. The accomplishment of science involves the efforts of many persons and their organizations. That is surely manifest in the work presented here. Modern science is very expensive and, consequently, financial resouces must be developed and distributed wisely. Those who facilitate this basic function have the appreciation of those of us who need the resources to do our work. There are a large number of individuals whose names will not appear in these pages that make subยญ stantial contributions. We are thankful for their daily contributions. The people who provide the money, those who distribute it, and those who help us do our work have the legitimate expectation that the sciยญ entists who use the resources will use it prudently. We hope that your expectations are fulfilled, and sincerely appreciate your efforts
CONTENT
Section 1 Background -- 1 Obesity, Anorexia Nervosa, and Bulimia: A General Overview -- 2 Alcohol-Abuse and Alcoholism -- 3 The Endogenous Opioidergic Systems -- 4 Opioidsโ{128}{153} Modification of Central Reward Processes -- Section 2 Opioids and Ingestion -- 5 Basic Mechanisms of Opioidsโ{128}{153} Effects on Eating and Drinking -- 6 Feeding Modified by Central Applications of Opioids -- Section 3 Using Opioid-Antagonists in Treating Bulimia -- 7 Naltrexone and Bulimia: Initial Observations -- 8 Using Drugs to Manage Binge-Eating Among Obese and Normal Weight Patients -- Section 4 Opioids and AA&A, Preclinical Studies -- 9 Opioids Modulate Ratsโ{128}{153} Intakes of Alcoholic Beverages -- 10 Opioids Modulate Ratsโ{128}{153} Reactivities to Alcohol -- Section 5 Naltrexone and Alcohol-Dependence -- 11 Naltrexone and the Treatment of Alcohol-Dependence: Initial Observations -- Section 6 Individual Differences -- 12 Enkephalinergic Involvement in Voluntary Drinking of Alcohol -- 13 Endorphins in Individuals with High and Low Risk for Development of Alcoholism -- 14 Do Substance-Abuse, Including Alcoholism, and Bulimia Covary? -- Section 7 Prospectives -- 15 Potential Toxicities of High Doses of Naltrexone in Patients with Appetitive Disorders -- 16 Prospects for Developing More Specific Antagonists, I -- 17 Prospects for Developing More Specific Antagonists, II -- 18 Summary -- References
