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AuthorTiwari, Jawahar L. author
TitleHLA and Disease Associations [electronic resource] / by Jawahar L. Tiwari, Paul I. Terasaki
ImprintNew York, NY : Springer New York, 1985
Connect tohttp://dx.doi.org/10.1007/978-1-4613-8545-5
Descript 472p. online resource

SUMMARY

The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine interยญ national histocompatibility workshops held during this period. Although idenยญ tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather unยญ expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al


CONTENT

1 HLA Nomenclature -- 2 The HLA Complex -- 3 The Data and Statistical Analysis -- 4 Mechanisms of HLA and Disease Associations -- 5 Overview -- 6 Rheumatology and Joint Diseases -- 7 Dermatology -- 8 Neurology -- 9 Endocrinology -- 10 Gastroenterology -- 11 Ophthalmology -- 12 Malignancy -- 13 Allergy -- 14 Urogenital Diseases -- 15 Cardiovascular Diseases -- 16 Connective Tissue Diseases -- 17 Pulmonary Diseases -- 18 Infectious Diseases -- 19 Musculoskeletal Diseases -- 20 Psychiatric Diseases -- 21 Hematologic Diseases -- 22 Complement and Immune Deficiencies -- 23 Immune Response -- 24 Miscellaneous Diseases


Medicine Human genetics Immunology Allergy Medicine & Public Health Allergology Immunology Human Genetics



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