Title | Glycoprotein Hormones [electronic resource] : Structure, Function, and Clinical Implications / edited by Joyce W. Lustbader, David Puett, Raymond W. Ruddon |
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Imprint | New York, NY : Springer New York, 1994 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-8386-4 |
Descript | XX, 381 p. online resource |
I. Reflections Past and Present -- 1. Reflections on Purifying Gonadotropins in the 1960s -- 2. Where to from Here? -- 3. Remembrance of Things Foregone -- II. Regulation of Gene Expression -- 4. Endocrine Regulation of Glycoprotein Hormone Alpha Subunit Gene Expression in Transgenic Mice -- 5. Coordinate Regulation of the Gonadotropin Subunit Genes in Pituitary and Placenta -- 6. Role of Helix-Loop-Helix Proteins in Gonadotropin Gene Expression -- 7. Cyclic AMP-Mediated Hormonal Regulation of Gene Transcription -- 8. Regulation and Expression of Thyroid Stimulating Hormone -- III. Hormonal Protein Structure/Function -- 9. Human Chorionic Gonadotropin: Progress in Determining Its Tertiary Structure -- 10. Receptor Binding Regions of hLH and hCG?-Subunit: Structural and Functional Properties -- 11. Evidence for Altered Splicing in Two Members of the Chorionic Gonadotropin ? Gene Cluster -- 12. Delineation of Subunit and Receptor Contact Sites by Site-Directed Mutagenesis of hCG? -- IV. Protein Processing and Posttranslational Events -- 13. Folding of the ?-Subunit of hCG and Its Role in Assembly of the ?-? Heterodimer -- 14. Structure and Function of the Gonadotropin Free ? Molecule of Pregnancy -- 15. Glycosylation and Glycoprotein Hormone Function -- V. Receptor Structure/Function -- 16. Structure and Regulated Expression of the TSH Receptor Gene: Differences and Similarities to Gonadotropin Receptors -- 17. Studies on the Structure and Function of Gonadotropins -- 18. Hormone Binding and Activation of the LH/CG Receptor -- VI. Clinical Implications -- 19. Use of the Free Alpha Subunit (FAS) of Glycoprotein Secreting Hormones as a Surrogate Marker of GnRH Secretion in the Human -- 20. Free hCG? and Nongonadal Neoplasms -- 21. New Clinical Applications of hCG Assays -- 22. ?-Core Fragment: Structure, Production, Metabolism, and Clinical Utility -- 23. Human Pituitary Chorionic Gonadotropin Is Produced, Circulated, and Excreted in Multiple Isoforms -- 24. Thyrotropin Abnormalities in Central Hypothyroidism -- Appendix: Poster Presentations -- Author Index