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TitleHemostatic Mechanisms and Metastasis [electronic resource] / edited by Kenneth V. Honn, Bonnie F. Sloane
ImprintBoston, MA : Springer US, 1984
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Descript XXII, 432 p. online resource


1. Is there Clinical Relevance for Therapies which Disrupt the Metastatic Cascade? -- 2. Overview of the Metastatic Cascade -- 3. Overview on Blood Coagulation Proteins -- 4. The Microinjury Hypothesis and Metastasis -- 5. Hemostatic Abnormalities in Tumor-Bearing Animals -- 6. Evidence for a Tumor Proteinase in Blood Coagulation -- 7. Relationship between Procoagulant Activity and Metastatic Capacity of Tumor Cells -- 8. Fibrin Formation: Implications for Tumor Growth and Metastasis -- 9. Perspectives on the Role of Platelets in Hemostasis and Thrombosis -- 10. Mechanisms of Platelet Aggregation by Murine Tumor Cell Spheroids -- 11. Heterogenous Mechanisms of Tumor Cell-Induced Platelet Aggregation with Possible Pharmacological Strategy Toward Prevention of Metastases -- 12. Tumor Cysteine Proteinases, Platelet Aggregation and Metastasis -- 13. Arachidonate Metabolism in Platelets and Blood Vessels -- 14. Prostacyclin/Thromboxanes and Tumor Cell Metastasis -- 15. Evidence for Altered Arachidonic Acid Metabolism in Tumor Metastasis -- 16. Calcium Channel Blockers: Inhibitors of Tumor Cell-Platelet-Endothelial Cell Interactions -- 17. Evidence for the Antimetastatic Effects of Coumarin Derivatives -- 18. Mitogenic Stimulation of Tumor Cells by Platelet Derived Growth Factors -- 19. Role of the Vascular Endothelium in Hemostasis -- 20. The Cellular Interactions of Metastatic Tumor Cells with Special Reference to Endothelial Cells and their Basal Lamina-Like Matrix -- 21. Interaction of Tumor Cells with the Basement Membrane of Endothelium -- 22. Hemostatic Alterations in Cancer Patients -- 23. Historical Overview of Clinical Experience with Anticoagulant Therapy -- 24. Rationale for Anticoagulant Treatment of Cancer -- 25. The Design and Execution of Anticoagulant Therapy Trials in Cancer -- 26. Experimental and Clinical Experience with Pyrimido โ{128}{148} Pyrimidine Derivatives in the Inhibition of Malignant Metastasis Formation -- 27. Current Clinical Trials with Anticoagulant Therapy in the Management of Cancer Patients

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