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TitleBiology and Therapy of Acute Leukemia [electronic resource] : Proceedings of the Seventeenth Annual Detroit Cancer Symposium Detroit, Michigan โ{128}{148} April 12-13, 1984 / edited by Laurence Baker, Frederick Valeriote, Voravit Ratanatharathorn
ImprintBoston, MA : Springer US, 1985
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Descript XII, 259 p. online resource


This year notes two major changes in the annual Detroit Cancer Symposium. The first is our intention of selecting topยญ ics of broad interest to the cancer community and examining the subject from both a basic laboratory and clinical viewpoint. In this way, the importance of both elements of cancer research are noted and the interplay between them emphasized. Further, we believe that Symposia such as this act to stimulate the basic scientist and clinician to continue their studies with the knowยญ ledge of the impact that each has upon the other and the necยญ essary cooperation required to solve the cancer problem. The second change is the publication of this Symposium. The preยญ vious sixteen were not committed to manuscript form. Given the change in format and intent of the series, we believe that this and subsequent volumes will make important contributions to the cancer literature. The topic of "Biology and Therapy of Acute Leukemia" was chosen for the first Symposium because of its historical signifยญ icance in cancer chemotherapy. The therapeutic rationale for human leukemia is the result of understanding the basic tumor biology largely derived from transplantable leukemias in experยญ imental animals. It is through these models, as discussed by Dr. Fred Valeriote, that we learned the cellular kinetics of leukemia, the antileukemic effects of new agents and the efยญ fect of growth perturbation by various chemotherapeutic agents and their combinations


1. The Impact of Treatment on the Natural History of Acute Leukemia -- 2. Experimental Rationale for Therapy in the Treatment of Acute Leukemia -- 3. Clinical Laboratory Methods Used for the Classification of Acute Leukemia -- 4. HTLV-II and Human Leukemia -- 5. Oncogene Expression and Arrangement in Human Leukemia -- 6. Clonal Variation and Phenotypic Progression in Retrovirus Transformed Leukemia Cells -- 7. Chemotherapeutic Agents as Differentiation Inducers -- 8. Modes of Drug Resistance in Acute Leukemias -- 9. The Evolution of Therapy for Acute Lymphatic Leukemia in Children -- 10. Prognostic Factors in Childhood Acute Lymphoblastic Leukemia: Correlation with Treatment Response -- 11. Clinical Trials in Adult ANLL: An Overview -- 12. Allogeneic Marrow Transplantation for Acute Nonlymphoblastic Leukemia in Adults -- 13. Treatment Choices for Patients with Acute Nonlymphocytic Leukemia in Remission: Chemotherapy and Bone Marrow Transplantation -- 14. Autologous Bone Marrow Transplantation in Acute Leukemia -- 15. Treatment of Leukemia and Lymphoma with Biological Response Modifiers -- 16. Transfusion Therapy for the Support of Leukemia Patients -- 17. Leukemia:Hemorrhagic and Thrombotic Complications

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