Interferon Alpha-2: Pre-Clinical and Clinical Evaluation [electronic resource] : Proceedings of the Symposium held in Adjunction with the Second International Conference on Malignant Lymphoma, Lugano, Switzerland, June 13, 1984 / edited by Daniel L. Kisner, J. F. Smyth
Interferon alpha-2 is a genetically engineered, highly purified pharmaceutical agent that has undergone extensive phase I and phase II clinical study in more than 1000 patients. The material has biological activity by intravenous, intramusยญ cular and subcutaneous routes. Clinical toxicity principally involves the 'influenยญ za like' syndrome previously seen with native interferons. Other important toxiยญ cities include anorexia, hepatitis, confusion and myelosuppression. Tolerable doses in multiple schedules and routes of administration have been determined. Phase II clinical trials with multiple routes and schedules of administration have been performed. Significant clinical activity has been found in nonยญ Hodgkin's lymphomas (both low grade and high grade), refractory and relapsing multiple myeloma, hairy cell leukemia, Kaposi's sarcoma, with suggestions of activity in Hodgkin's disease, renal cell carcinoma, and melanoma. The studies performed to date have for the most part involved small numbers of heavily pre-treated patients. Large-scale clinical trials in some of these diseaยญ ses are now warranted in populations of patients with as little bulk disease and prior treatment as is feasible for each tumour type. This is particularly the case in . Hodgkin's disease and subcategories of the non-Hodgkin's lymphomas. Alternaยญ tely, interferon alpha-2 might be used to maintain remissions induced by other modalities (i. e. , in NHL, multiple myeloma, ovarian cancer). In some advanced disease settings, combinations of interferon alpha-2 with chemotherapeutic agents should now be investigated
CONTENT
1. Recombinant DNA Technology and Characterization of Recombinant Alpha-2 Interferon -- 2. Summary of Pre-Clinical Data -- 3. Synergy In Vitro and in Clinical Trials -- 4. Discussion: Pre-Clinical Panel -- 5. Phase I/II Clinical Trials -- 6. Phase II Evaluation in Patients with Non-Hodgkinโs Lymphoma. The Old World Experience. An Interim Report -- 7. High and Low Dose Treatment for High and Low Grade Non-Hodgkinโs Lymphoma -- 8. Use in Patients with Resistant and Relapsing Multiple Myeloma. A Phase II Study -- 9. Use in Hairy Cell Leukemia. An Update -- 10. Clinical Trials in Non-Hematologic Malignancies -- 11. Discussion: Clinical Panel -- 12. Conclusion
