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TitleClinical Evaluation of Antitumor Therapy [electronic resource] / edited by Franco M. Muggia, Marcel Rozencweig
ImprintBoston, MA : Springer US, 1987
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Descript XII, 220 p. online resource


The methodology of drug development has been the subject of extensive disยญ cussion by a relatively small group of individuals in industry and government who have been intimately concerned with the identification and study of new anticancer drugs. The Chemotherapy Program of the National Cancer Inยญ stitute has represented the major focus of initial efforts in drug development, as summarized in the historical perspective presented in chapter 1 and its references. It is no coincidence that the Chemotherapy Program was the origin of the Division of Cancer Treatment, a government entity that has had a pivotal role in the growth of clinical oncology. In an analogous fashion this book presents the methodology employed in the clinical study of anticancer drugs within the broad context of cancer treatment. The research orientation promulgated in the study of new drugs is a central theme in most oncoloยญ gists' approach to the clinical problem of cancer. Therefore, we hope that this book will introduce readers to treatment research in clinical oncology. For the oncologist, the clinical evaluation of antitumor therapy is both part of the day-to-day management of specific patients and the critical consideraยญ tion of developing therapeutic alternatives. For physicians in other fields of medicine it is important to acquaint themselves with the basic tools of the oncologist. For people without medical training, including patients who might be interested in treatment research, many of the chapters may be overly technical


1. General issues in anticancer drug development -- 2. Animal tumor models for experimental therapy -- 3. Experimental therapy: In vitro models -- 4. Clinical Evaluation: Noninvasive methods -- 5. Clinical evaluation: Biochemical methods -- 6. Anatomic and surgical principles in cancer clinical trials -- 7. Experimental toxicology -- 8. The phase I study: General objectives, methods, and evaluation -- 9. Clinical evaluation of anticancer treatments: Phase II clinical trials -- 10. Analysis of clinical trial data -- 11. The strategy of cancer treatment

Medicine Oncology Medicine & Public Health Oncology


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