Title | Chemical Mutagens [electronic resource] : Principles and Methods for Their Detection Volume 9 / edited by Frederick J. de Serres |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1984 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-2147-7 |
Descript | 572 p. online resource |
1 In Vivo Mutagenicity Testing Using Somatic Cells of Drosophila melanogaster -- 1. Introduction -- 2. Basic Developmental Biology of Drosophila -- 3. The Wing Mosaic System -- 4. The White/White-Coral Eye Mosaic System -- 5. The Unstable White-Zeste Eye Mosaic System -- 6. Exposure Techniques -- 7. Discussion -- 8. Conclusions -- 9. References -- 2 Structural and Metabolic Parameters Governing the Mutagenicity of Polycyclic Aromatic Hydrocarbons -- 1. Introduction -- 2. Activation Pathways of PAHs -- 3. Contribution of Different Activation Pathways to the Mutagenicity of PAHs -- 4. Metabolic Control of Mutagenic Intermediates of PAHs -- 5. Summary and Conclusions -- 6. Addendum: Recent Developments -- 7. References -- 3 Chromosomal Mutations: The Genetic Approach -- 1. Introduction -- 2. The Main Categories of Chromosomal Mutation -- 3. Genetic Detection of Aneuploidy in the Mouse -- 4. Reciprocal Translocations: Detection and Analysis -- 5. Detection and Study of Other Translocations and of Inversions -- 6. Detection and Study of Deletions -- 7. Conclusions -- 8. References -- 4 Cytogenetic Assays for Mitotic Poisons Using Somatic Animal Cells -- 1. Introduction -- 2. Mitotic Poisons and Their Genomic Effects -- 3. Assays with Diploid Mammalian Cells in Vitro -- 4. Assays with Bone Marrow Cells in Vivo -- 5. Assays with Grasshopper Embryos -- 6. Conclusions -- 7. References -- 5 Detection of Aneuploidy in Drosophila -- 1. Introduction -- 2. Issues -- 3. Assay Systems -- 4. Known Positives -- 5. Summary -- 6. References -- 6 Mammalian Cytogenetic and Genetic Tests for Nondisjunction -- 1. Introduction -- 2. Cytogenetic Tests -- 3. Genetic Test Systems with the Mouse -- 4. Summary and Conclusions -- 5. References -- 7 Using Repair-Deficient Chinese Hamster Ovary Cells to Study Mutagenesis -- 1. Introduction -- 2. Genetic and Biochemical Properties of Repair-Deficient Mutants -- 3. Hypersensitivity of Repair Mutants to DNA-Damaging Agents -- 4. Rapid Detection of DNA-Damaging Agents by Differential Cytotoxicity (DC) -- 5. Conclusions -- 6. References -- 8 Transplacental Genotoxic Agents: Cytogenetic Methods for Their Detection -- 1. Introduction -- 2. Animal Studies -- 3. Human Studies -- 4. References -- 9 Computer Automation of Metaphase Finding, Sister Chromatid Exchange, and Chromosome Damage Analysis -- 1. Introduction -- 2. Historical Trends in Computer Automation -- 3. Development of a System for Cytogenetic Mutagenicity Testing -- 4. Future Prospects for Full Automation -- 5. References -- 10 Mutagen-Sensitive Mutants and Chemical Mutagenesis in Drosaphila -- 1. Introduction -- 2. Isolation and Localization of Mutants -- 3. Biochemical Characteristics -- 4. Larval Exposure -- 5. Adult Exposure -- 6. Maternal Effects -- 7. Storage Effect -- 8. Conclusions -- 9. References -- 11 Chromosomal Causes for Fertility Reduction in Mammals -- 1. Introduction -- 2. Numerical Chromosome Mutations of the Sex Chromosomes and Related Conditions -- 3. Structural Chromosome Anomalies -- 4. Combinations of Chromosome Mutants within One Carrier -- 5. Viable Unbalanced Progeny Obtained from Translocation Heterozygote Females and Males -- 6. Why is Chromosomal Infertility More Clearly Expressed in the Male Than in the Female? Consideration of X-Autosome Translocations -- 7. References -- 12 Mutagenesis and Plasmids -- 1. Introduction -- 2. Historical Overview of Plasmids -- 3. Survey of Thirty-Three R Plasmids -- 4. Mechanisms of Plasmid-Mediated Effects on Mutagenesis and Survival -- 5. References -- 13 Mutation in Somatic Cells as Determined by Electrophoretic Analysis of Mutagen-Exposed Chinese Hamster Ovary Cells -- 1. Introduction -- 3. Results and Discussion -- 4. Summary -- 5. References