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TitlePhysiology of Membrane Disorders [electronic resource] / edited by Thomas E. Andreoli, Joseph F. Hoffman, Darrell D. Fanestil, Stanley G. Schultz
ImprintBoston, MA : Springer US, 1986
Edition Second Edition
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Descript 1094 p. 383 illus. online resource


The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition . Yet the purpose ofthe second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably. THE EDITORS xi Preface to the First Edition The purpose of this book is to provide the reader with a rational frame of reference for assessing the paยญ thophysiology of those disorders in which derangements of membrane transport processes are a major factor responsible for the clinical manifestations of disease. In the present context, we use the term "membrane transport to refer to those molecular processes whose cardinal function, broadly speaking, is processes" in a catholic sense, the vectorial transfer of molecules-either individually or as ensembles-across biological interfaces, the latter including those interfaces which separate different intracellular compartments, the cellular and extracellular comยญ partments, and secreted fluids-such as glomerular filtrate-and extracellular fluids


I: The Nature of Biological Membranes -- 1: The Anatomy of Biological Interfaces -- 2: Composition and Dynamics of Lipids in Biomembranes -- 3: Membrane Proteins: Structure, Arrangement, and Disposition in the Membrane -- II: Methods for Studying Membranes -- 4: The Nature and Limitations of Electron Microscopic Methods in Biology -- 5: Isolation and Characterization of Biological Membranes -- 6: Absorption and Optical Rotation Spectra of Biological Membranes: Distortions and Their Corrections -- 7: Mathematical Models of Membrane Transport Processes -- 8: Application of Tracers to the Study of Membrane Transport Processes -- 9: Principles of Electrical Methods for Studying Membrane Movements of Ions -- 10: The Study of Transport and Enzymatic Processes in Reconstituted Biological Systems -- III: General Problems in Membrane Biology -- 11: Principles of Water and Nonelectrolyte Transport across Membranes -- 12: Anion Transport in Erythrocytes -- 13: Active Transport of Na+ and K+ by Red Blood Cells -- 14: Weak Electrolyte Transport across Biological Membranes: General Principles -- 15: Ion Permeation in Cell Membranes -- 16: Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum -- 17: Ion-Coupled Transport of Organic Solutes across Biological Membranes -- 18: Bioenergetics of Membrane Transport Processes -- 19: Regulation of Cellular Volume -- 20: Cell-to-Cell Communication: Permeability, Regulation, Formation, and Functions of the Cell-Cell Membrane Channel in Cell Junctions -- 21: Genes and Membranes -- 22: The Interaction of Hormones with Biological Membranes -- 23: Modification of Membrane Function by Drugs -- IV: Transport Events in Single Cells -- 24: Active Transport in Escherichia Coli: From Membrane to Molecule -- 25: Acidification of Intracellular Organelles: Mechanism and Function -- 26: Intracellular pH Regulation -- 27: Properties of Ionic Channels in Excitable Membranes -- 28: Ion Movements in Skeletal Muscle in Relation to the Activation of Contraction -- 29: Excitable Tissues: The Heart -- 30: Ion Transport through Ligand-Gated Channels -- V: Transport in Epithelia: Vectorial Transport through Parallel Arrays -- 31: Cellular Models of Epithelial Ion Transport -- 32: Ion Transport by Gastric Mucosa -- 33: Ion and Water Transport in the Intestine -- 34: The Uptake of Lipids into the Intestinal Mucosa -- 35: Mechanisms of Bile Secretion and Hepatic Transport -- 36: The Regulation of Glomerular Filtration Rate in Mammalian Kidneys -- 37: The Proximal Nephron -- 38: The Effects of ADH on Salt and Water Transport in the Mammalian Nephron: The Collecting Duct and Thick Ascending Limb of Henle -- 39: Urinary Concentrating and Diluting Processes -- 40: Transport Functions of the Distal Convoluted Tubule -- 41: The Respiratory Epithelium -- VI: Clinical Disorders of Membrane Transport Processes -- 42: The Cellular Basis of Ischemic Acute Renal Failure -- 43: Genetic Variants Affecting the Structure and Function of the Human Red Cell Membrane -- 44: Inherited Membrane Disorders of Muscle: Duchenne Muscular Dystrophy and Myotonic Muscular Dystrophy -- 45: Disorders of Muscle: The Periodic Paralyses -- 46: Pathophysiology of Cardiac Arrhythmias -- 47: Pathophysiology of Peptic Ulcer Disease -- 48: Malabsorption Syndromes -- 49: Pathophysiology of Calcium Absorptive Disorders -- 50: Cystic Fibrosis -- 51: Disorders of Glomerular Filtration -- 52: The Hypertonic and Hypotonic Syndromes -- 53: Disorders of Proton Secretion by the Kidney -- 54: Cystinosis and the Fanconi Syndrome -- 55: Renal Tubular Defects in Phosphate and Amino Acid Transport -- 56: Pulmonary Edema

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