Title | White cells and platelets in blood transfusion [electronic resource] : Proceedings of the Eleventh Annual Symposium on Blood Transfusion, Groningen 1986, organized by the Red Cross Blood Bank Groningen-Drenthe / edited by Cees Th. Smit Sibinga, Prakash C. Das, C. Paul Engelfriet |
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Imprint | Boston, MA : Springer US, 1987 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-2089-0 |
Descript | XIV, 284 p. online resource |
I. Principles and functional aspects -- The human MHC (HLA) and immediate relevance in transfusion Practice -- Alloimmunization against platelets and granulocytes -- Leukocytes in transfusion medicine โ an overview of functions and clinical implications -- Platelet functions and platelet transfusion -- Discussion -- II. Clinical Aspects -- A.Presence of cells -- Platelet transfusion -- Prospective selection of compatible platelet donors for alloimmunized patients by an ELISA platelet cross-match only -- White blood cell transfusions in the immuno-compromised patients -- Immunization with antigen-bound antibody: an experimental approach to prevention of sensitization to allogeneic blood cells -- Autologous bone marrow transplantation in acute myeloblastic leukemia (AML): in vitro studies to detect minimal disease in remission marrow -- Autologous bone marrow transplantation in solid malignancies -- Discussion -- Clinical use of leukocyte poor red cell concentrates -- Management and prevention of cytomegalovirus infection -- Graft-versus-Host disease and the role of blood product irradiation -- Perspectives for lymphokine therapy: from genetic engineering to immunologic engineering -- Discussion -- III. Production aspects -- Practical aspects of platelet concentrate production and storage -- Surge plateletapheresis -- Platelets and propylene glycol: an approach to freezing platelets in the presence of a new cryoprotectant -- Bacterial contamination in platelets stored at ambient temperature -- Preparation of leukocyte-poor blood -- Use of hemapheresis-derived hemopoietic stem cells for transplantation in malignant lymphohemopoietic disorders -- Purging of bone marrow -- Discussion -- IV. Laboratory aspects -- HLA-matching and crossmatching in platelet transfusion -- Cell culture and immune function tests -- Platelet antibody detection -- Decreased fluidity of human platelet membranes after interaction with an anti PLA1 antibody -- Role of white cells in reagents for AIDS -- Discussion