Title | Organ Directed Toxicities of Anticancer Drugs [electronic resource] / edited by Miles P. Hacker, John S. Lazo, Thomas R. Tritton |
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Imprint | Boston, MA : Springer US, 1988 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-2023-4 |
Descript | XII, 254 p. online resource |
Keynote Address -- The Irrelevant Toxicities of Anticancer Drugs -- Section I: Anthracycline Induced Cardiotoxicity -- Overview -- Role of Iron in Anthracycline Action -- Role of Reactive Oxygen Production in Doxorubicin Cardiac Toxicity -- Adriamycin Cardiac Toxicity โ An Assessment of Approaches to Cardiac Monitoring and Cardioprotection -- Pretreatment with ICRF-187 Protects Against the Chronic Cardiac Toxicity Produced by Very Large Cumulative Doses of Doxorubicin in Beagle Dogs -- A Trial of ICRF-187 to Selectively Protect Against Chronic Adriamycin Cardiac Toxicity: Rationale and Preliminary Results of a Clinical Trial -- Section II: Bleomycin Induced Pulmonary Toxicity -- Overview -- Base Propenals and the Toxicity of Bleomycin -- Bleomycin Induced Lung Injury -- Immunoregulation of Growth Factor Release in Bleomycin Induced Lung Disease -- Pulmonary Toxicity of Anticancer Drugs: Alterations in Endothelial Cell Function -- Pulmonary Metabolic Inactivation of Bleomycin and Protection from Drug Induced Lung Injury -- Biochemical and Molecular Bases of Bleomycin Induced Pulmonary Fibrosis: Glucocorticoid Intervention -- Section III: Platinum Induced Nephrotoxicity -- Overview -- Factors Influencing the Formation and Persistence of Platinum-DNA Adducts in Tissues of Rats Treated with Cisplatin -- Cisplatin Nephrotoxicity: New Insights into Mechanism -- Experimental Approaches to Reducing Platinum Induced Kidney Toxicity -- High Dose Cisplatin with Hypertonic Saline: Toxicity and Therapeutic Results -- Section IV: Poster Presentations -- Titles and Authors -- Abstracts -- Author Index