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TitleDevelopment and Recognition of the Transformed Cell [electronic resource] / edited by Mark I. Greene, Toshiyuki Hamaoka
ImprintBoston, MA : Springer US, 1987
Connect tohttp://dx.doi.org/10.1007/978-1-4613-1925-2
Descript XVI, 476 p. 39 illus. online resource

SUMMARY

The study of the phenotypic and genetic features that characterize the malignant cell is a rapidly growing and changing field. Clearly new insights into the processes involved in normal and abnormal cell growth will facilitate our understanding of events relevant to cancer and cellular differentiation. Early studies on genetic feaยญ tures associated with cancer focused on chromosomal abnormalities that were observable in several human malignancies. The more recent examination of oncoยญ genes and the proteins they encode has helped pinpoint many steps in different processes that might be involved in cancer. Immunologic studies of cancer have also developed from an imprecise series of investigations to a more detailed molecular examination of cell-surface strucยญ tures that can be recognized immunologically. In the course of the development of modern tumor immunology, it has become clear that many of the antigens that can be recognized appear to be the products of genes involved in cell growth. Furยญ thermore, changes in the cell surface of malignant cells have often been found to include alteration of nonprotein constituents


CONTENT

1 Cytogenetics of Neoplasia -- 2 The Structure and Function of the Normal c-myc Gene and Its Alteration in Malignant Cells -- 3 Protooncogene Expression in Lymphoid Cells: Implications for the Regulation of Normal Cellular Growth -- 4 Oncogene Products as Receptors -- 5 Monoclonal Antibodies Reactive with the neu Oncogene Product Inhibit the Neoplastic Properties of neu-Transformed Cells -- 6 Relationship of the c-fms Protooncogene Product to the CSF-1 Receptor -- 7 Two erbB-Related Protooncogenes Encoding Growth Factor Receptors -- 8 The Receptor for Epidermal Growth Factor -- 9 The Role of the abl Gene in Transformation -- 10 Comparison of the Structural and Functional Properties of the Viral and Cellular src Gene Products -- 11 Protein Kinase C as the Site of Action of the Phorbol Ester Tumor Promoters -- 12 Involvement of Human Retrovirus in Specific T-Cell Leukemia -- 13 Mechanisms of Virus-Induced Alterations of Expression of Class I Genes and Their Role on Tumorigenesis -- 14 Antigenic Requirements for the Recognition of Moloney Murine Leukemia Virus-Induced Tumors by Cytotoxic T Lymphocytes -- 15 SV40 Tumor Antigen: Importance of Cell Surface Localization in Transformation and Immunological Control of Neoplasia -- 16 Correlation of Natural Killer Cell Recognition with ras Oncogene Expression -- 17 A Regulatory Role of Natural Killer Cells (LGL) in T-Cell-Mediated Immune Response -- 18 Immune Regulation in Neoplasia: Dominance of Suppressor Systems -- 19 The Generation and Down-Regulation of the Immune Response to Progressive Tumors -- 20 Origin and Significance of Transplantation Antigens Induced on Cells Transformed by UV Radiation -- 21 Cellular and Molecular Mechanisms Involved in Tumor Eradication in Vivo -- 22 Application of T Cell-T Cell Interaction to Enhanced Tumor-Specific Immunity Capable of Eradicating Tumor Cells in Vivo -- 23 Antigens Expressed by Melanoma and Melanocytes: Studies of the Immunology, Biology, and Genetics of Melanoma -- 24 Malignant Transformational Changes of the Sugar Chains of Glycoproteins and Their Clinical Application -- 25 Ganglioside Involvement in Tumor Cell-Substratum Interactions -- 26 Specific Adoptive Therapy of Disseminated Tumors: Requirements for Therapeutic Efficacy and Mechanisms by Which T Cells Mediate Tumor Eradication


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