I. Ionic Determinants of Electrical Activity -- 1. Calcium current and excitation-contraction coupling in heart. -- 2. Role of cytosolic calcium in the normal and ischemic heart: potential new insights from the second generation indicator, Indo-1. -- 3. Repetitive activity: origin of the Na+ load and its physiologic effects. -- 4. Ionic changes associated with acute ischemia. -- 5. Mechanisms of reperfusion arrhythmias. -- II. Metabolic Factors in Ischemia -- 6. Ischemia and Na+/K+ pump function. -- 7. Amphipathic lipid metabolites and arrhythmogenesis: a perspective. -- 8. Free radicals and myocardial injury during ischemia and reperfusion: a short-lived phenomenon? -- 9. Thyroid hormones and cardiac function. -- III. Neural and Hormonal Factors -- 10. Receptor mechanisms in ischemia and infarction. -- 11. Sympathetic-parasympathetic interactions in the normal heart. -- 12. Central nervous system modulation of cardiac rhythm. -- 13. Influence of ischemia and infarction on cardiac vagal and sympathetic innervation. -- IV. Arrhythmogenic Nechanisms -- 14. On the problem of anisotropic propagation in ventricular muscle. -- 15. Anisotropic reentry: A model of arrhythmias that may necessitate a new approach to antiarrhythmic drug development. -- 16. Arrhythmias in the early ischemic period. -- 17. Arrhythmias and the healed myocardial infarction. -- V. Strategies for Prediction, Prevention and Therapy -- 18. Clinical significance and limitations of ventricular late potentials. -- 19. Pacing to predict mechanism: transient entrainment and reentry. -- 20. The value of programmed electrical stimulation in triggered activity-induced arrhythmias. -- 21. Pharmacologic mechanisms in the treatment of arrhythmias due to ischemia and infarction. -- 22. Cardiac innervation and sudden death: new strategies for prevention