Title | Cancer Imaging with Radiolabeled Antibodies [electronic resource] / edited by David M. Goldenberg |
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Imprint | Boston, MA : Springer US, 1990 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-1497-4 |
Descript | XXII, 468 p. online resource |
I. Historical and Theoretical Perspectives -- 1. Clinical radioimmunodetection: The second decade -- 2. Antibody targeting: Theoretical considerations -- II. Model Systems -- 3. Experimental model systems for antibody targeting and radioimmunodetection -- 4. Preclinical models and methods for the study of radiolabeled monoclonal antibodies in cancer diagnosis and therapy -- 5. Physiology of monoclonal antibody accretion by tumors -- 6. Intraperitoneal delivery of monoclonal antibodies -- III. Radiochemistry -- 7. Chelates and antibodies: Current methods and new directions -- 8. Radiolabeling antibodies via the cyclic anhydride of DTPA โ Experiences of 5 years -- 9. Bifunctional chelating agents for radiometal-labeled monoclonal antibodies -- 10. Optimization of biodistribution by introducing different chemical linkages between antibody and an indium-111 chelate -- 11. Novel bifunctional linkers for antibody chelation with radiometals -- 12. Labeling of anti-tumor antibodies and antibody fragments with Tc-9m -- IV. Clinical Studies -- 13. Requirements for the use of radioimmunodetection of cancer in clinical practice -- 14. In-vivo antibody imaging for the detection of human tumors -- 15. In-111 monoclonal antibody immunoscintigraphy of colorectal cancer -- 16. Tumor targeting with monoclonal antibody B72.3: Experimental and clinical results -- 17. Antibody imaging of endocrine tumors -- 18. Diversity of the human immune response to clinically used murine monoclonal antibodies -- V. New Approaches -- 19. Antibody lymphoscintigraphy -- 20. Radioimmunoguided surgery: A new intraoperative approach to the detection of tumor -- 21. Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas -- 22. Anti-antibody enhancement of tumor imaging