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TitleCancer Imaging with Radiolabeled Antibodies [electronic resource] / edited by David M. Goldenberg
ImprintBoston, MA : Springer US, 1990
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Descript XXII, 468 p. online resource


Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textยญ books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more


I. Historical and Theoretical Perspectives -- 1. Clinical radioimmunodetection: The second decade -- 2. Antibody targeting: Theoretical considerations -- II. Model Systems -- 3. Experimental model systems for antibody targeting and radioimmunodetection -- 4. Preclinical models and methods for the study of radiolabeled monoclonal antibodies in cancer diagnosis and therapy -- 5. Physiology of monoclonal antibody accretion by tumors -- 6. Intraperitoneal delivery of monoclonal antibodies -- III. Radiochemistry -- 7. Chelates and antibodies: Current methods and new directions -- 8. Radiolabeling antibodies via the cyclic anhydride of DTPA โ{128}{148} Experiences of 5 years -- 9. Bifunctional chelating agents for radiometal-labeled monoclonal antibodies -- 10. Optimization of biodistribution by introducing different chemical linkages between antibody and an indium-111 chelate -- 11. Novel bifunctional linkers for antibody chelation with radiometals -- 12. Labeling of anti-tumor antibodies and antibody fragments with Tc-9m -- IV. Clinical Studies -- 13. Requirements for the use of radioimmunodetection of cancer in clinical practice -- 14. In-vivo antibody imaging for the detection of human tumors -- 15. In-111 monoclonal antibody immunoscintigraphy of colorectal cancer -- 16. Tumor targeting with monoclonal antibody B72.3: Experimental and clinical results -- 17. Antibody imaging of endocrine tumors -- 18. Diversity of the human immune response to clinically used murine monoclonal antibodies -- V. New Approaches -- 19. Antibody lymphoscintigraphy -- 20. Radioimmunoguided surgery: A new intraoperative approach to the detection of tumor -- 21. Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas -- 22. Anti-antibody enhancement of tumor imaging

Medicine Immunology Radiology Oncology Medicine & Public Health Oncology Immunology Imaging / Radiology


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