Title | Drug Resistance [electronic resource] / edited by William N. Hait |
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Imprint | Boston, MA : Springer US, 1996 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-1267-3 |
Descript | XVIII, 418 p. online resource |
I. Membrane Transport Mechanism -- 1. P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal -- 2. Multidrug Resistance Associated with Overexpression of MRP -- II. Resistance to Alkylating Agents -- 3. Mechanisms of Resistance to Alkylating Agents -- 4. Glutathione S-Transferases -- 5. Role of DNA Repair in Resistance to Drugs that Alkylate O6 of Guanine -- III. Resistance to Microtubule Active Drugs -- 6. Paclitaxel (Taxolยฎ): Mechanisms of Resistance -- IV. Resistance to Antimetabolites -- 7. Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy -- 8. Antifolates: Current Developments -- 9. Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance -- 10. Cellular Resistance to Topoisomerase Poisons -- VI. Resistance to Endocrine Therapies -- 11. Acquisition of an Antiestrogen Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms -- 12. Androgen Receptor Mutations in Prostate Cancer -- VII. Resistance to Retinoids -- 13. Retinoids in Clinical Cancer Therapy -- VIII. Novel Mechanisms and Approaches -- 14. Apoptosis and Cancer Chemotherapy -- 15. Interaction of Chemotherapy and Biological Response Modifiers in the Treatment of Melanoma -- 16. Multifunctional Modulators of Drug Resistance