Title | Immunotoxins [electronic resource] / edited by Arthur E. Frankel |
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Imprint | Boston, MA : Springer US, 1988 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-1083-9 |
Descript | XX, 566 p. online resource |
1. Introduction -- I. Toxin Structure -- 2. Toxin structure -- 3. Structureโactivity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A -- II. How Toxins Work -- 4. How protein toxins enter and kill cells -- 5. Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes -- III. Toxin Selection and Modification -- 6. Toxin selection and modification โ Overview -- 7. Toxin selection and modification: Utilization of the A chain of ricin -- 8. Genetic engineering of immunotoxins -- 9. Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development -- 10. Immunotoxins containing ricin -- 11. Pseudomonas exotoxin โ Immunotoxins -- 12. Immunotoxins containing single chain ribosome-inactivating proteins -- IV. Covalent Linking Agents -- 13. Antibody-toxin conjugation -- 14. Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins -- V. Antibody Selection -- 15. Immunotoxins: Selection of cell-surface antigens and their corresponding monoclonal antibodies -- VI. Nonantibody Ligands -- 16. Hormone, lectin and toxin-toxin conjugates -- 17. Growth factors and other ligands -- VII. Purification and Chemical Characterization -- 18. Purification and biochemical characterization of immunotoxins -- VIII. Enhancers -- 19. Immunotoxin enhancers -- 20. Enhancement of immunotoxin action: Manipulation of the cellular routing of proteins -- IX. Cytotoxicity -- 21. Methods for quantifying immunotoxin efficacy -- 22. Kinetic analysis of cytotoxicity -- 23. Isolation and analysis of somatic cell mutants resistant to toxin conjugates -- X. Animal Studies -- 24. Immunotoxin therapy: Assessment by animal models -- 25. Prevention of carbohydrate-mediated clearance of ricin-containing immunotoxins by the liver -- 26. Human immune response to immunotoxins -- XI. Clinical Studies -- 27. Treatment of leukemia patients with T101 ricin A chain immunotoxins -- 28. Clinical studies: Solid tumors -- 29. Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation -- 30. Conclusion