Title | Experimental Hepatocarcinogenesis [electronic resource] / edited by M. B. Roberfroid, V. Prรฉat |
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Imprint | Boston, MA : Springer US, 1988 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-0957-4 |
Descript | 332 p. online resource |
Experimental and Human Liver Carcinogenesis: Cause and Modulation -- Hepatocarcinogens -- The Induction of Localized Tumors by Carcinogens Implanted into the Liver -- Two Stage Theory of Carcinogenesis: a critical review Introducing the Concept of Modulation -- Modulating Factors of Hepatocarcinogenesis -- Sex Hormones as Modulators of Liver Tumor Development -- Liver Cancer and Viruses -- Morphological Alterations During Liver Carcinogenesis -- Metabolic Zonation of the Liver -- Cellular Differentiation during Neoplastic Development in the Liver -- Histochemical Analysis of Hepatocarcinogenesis -- Cell Proliferation, Cell Death and Liver Carcinogenesis -- Cell Proliferation and Hepatocarcinogenesis -- Initiation of Chemical Hepatocarcinogenesis: Compensatory Cell Proliferation versus Mitogen Induced Hyperplasia -- Cell Death (Apoptosis) in Normal and Preneoplastic Liver Tissue -- Biochemical Alterations During Liver Carcinogenesis -- A Study of the Activities of Carbohydrate Metabolizing. Enzymes and the Levels of Carbohydrate Metabolites and Amino Acids in Normal Liver and in Hepatocellular Carcinoma -- The Expression of Cell Surface Receptors in Regenerating and Neoplastic Liver Tissue -- Cholesterol Metabolism during Cell Proliferation -- Mechanism of the Inhibition of Liver Carcinogenesis Promotion by S-adenosyl-L-methionine -- Nuclear and Genetic Alterations During Liver Carcinogenesis -- Long Term Effect of Diethylnitrosamine (DEN) on the Production of Micronuclei in Precancerous Rat Liver -- Nuclear Alterations during Hepatocarcinogenesis: Promotion by 2-acetylaminofluorene -- Cytogenetic and Genetic Alterations during Hepatocarcinogenesis -- Role of Oncogenes in Hepatocarcinogenesis -- In Vitro Studies in Liver Carcinogenesis -- Separation and Biochemical Characterization of Rat Liver Parenchymal Cell Subpopulations -- Growth Control of Hepatocytes, their Immortalization and Transformation by Transforming Genes of Polyoma Virus and of SV40 Virus -- Changes in Hepatocyte TGF? Receptors and Gene Expression during Normal and Neoplastic Liver Growth -- Regulation of Carbohydrate Metabolism in a Glycogenstoring Liver Cell Line -- Techniques in Measuring DNA Synthesis and Mitosis Induced by Tumor Promoters in Hepatocytes Primary Cultures -- Conclusions -- Concluding Remarks -- Contributors