Author | Abel, Ernest L. author |
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Title | Behavioral Teratogenesis and Behavioral Mutagenesis [electronic resource] : A Primer in Abnormal Development / by Ernest L. Abel |
Imprint | Boston, MA : Springer US, 1989 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-0735-8 |
Descript | 254 p. online resource |
1. In the Beginning Was the Word and the Word Was โฆ DNA -- The Living Cell -- Mendelโs Model -- Chromosome Theory -- The Cell Cycle -- Mitosis -- Meiosis -- Gametogenesis -- Sperm Imprinting -- Genetic Variability -- Gene Theory -- The Double Helix -- How DNA Sends Messages -- You Are a Degenerate -- Junk Genes? -- What Turns You On? -- Pleiotropy -- Epistasis -- The Molecular Clock -- Finding Eve -- The Origin of Species -- Genetic Engineering -- References -- 2. Behavior Genetics -- The Heritability of Behavior -- Paradigms Used in Human Behavioral Genetics Research -- Schizophrenia -- Alzheimer Disease -- Alcoholism -- Phenylketonuria -- Fragile X -- Intelligence -- A Flutist Needs a Flute to Be a Flutist -- Prenatal Learning in the Classwomb -- References -- 3. Some DNA Is Born Great, Some Never Achieves Its Greatness, and Some Has Its Greatness Poisoned before It Can Be Recognized -- Sources of Mutations: Spontaneous versus Induced -- Types of Mutations -- Somatic versus Gametic Mutations -- Categories of Mutations -- Conditional Mutations -- Point Mutation -- Death by Beans -- Sister Chromatid Exchange -- Chromosomal Mutations -- Down Syndrome -- Sex Chromosome Anomalies -- Genome Mutations -- Agents Causing Mutations -- Ultraviolet Radiation -- Chemical Causes of Mutation -- Some Laboratory Tests for Mutagens -- DNA Repair Mechanisms -- Appendix A. Prenatal Testing -- References -- 4. From Gene to Brain -- Preimplantation -- Implantation -- Gastrulation -- Induction -- Critical Period -- The Beginning of a Brain -- Proliferation -- Cell Migration -- Pattern Formation -- Differentiation -- Relationship of Animal Brain Development to Human Brain Development -- The Neuron -- The Nerve Impulse -- Synaptogenesis -- Neurotransmitters as Inducers -- Long-Range Induction -- Glia and Myelination -- Modification of Synaptic Connections -- Appendix A. Malformations of CNS Development Due to Failure of Neuropore Closure -- Appendix B. Basic Functional Neuroanatomy -- Appendix C. Research Techniques in Neuroanatomy and Neurophysiology -- References -- Chapters 5. Behavioral Teratogenesis -- Behavioral Teratology -- Principles of Teratology -- Appendix A. Routes of Administration -- References -- 6. Identifying Human Behavioral Teratogens: Designs and Methods -- Definition of Birth Defects -- Ascertainment -- Population Being Evaluated -- Procedures for Identifying Teratogens -- Descriptive Studies -- Analytical Evaluations -- Apgar Test -- Prechtl Exam -- The Brazelton Test -- Scanlon -- Bayley Scales -- Visual Recognition Memory -- Reaction Time -- Intelligence Tests -- Summary and Conclusions -- Appendix A. Diagnostic Criteria for Attention Deficit Disorder with Hyperactivity -- References -- 7. Testing Animal Behavioral Teratogens: Designs and Methods -- Rationale for Studies in Animals -- Methodological Issues -- Test Methods -- Developmental Landmarks -- Learning/Memory Tasks -- Active Avoidance -- Passive Avoidance -- Maze Learning -- Spontaneous Alteration -- Reversal Learning -- Activity -- Observational Techniques -- Rotorod -- Preference Tests -- Sexual Behavior in the Rat -- Acoustic Startle -- Seizure Susceptibility -- Operant Behavior -- Sensitivity to Drugs -- References -- 8. Regulatory Protocols for Identifying Teratogens -- FDA Guidelines -- Behavioral Teratology Testing in Japan -- Behavioral Teratology Testing in the United Kingdom -- Behavioral Teratology Testing in France and Italy -- Efforts to Create a Behavioral Teratology Test Battery in the United States -- Summary and Conclusions -- References