Title | Issues and Reviews in Teratology [electronic resource] : Volume 5 / edited by Harold Kalter |
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Imprint | Boston, MA : Springer US, 1990 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-0521-7 |
Descript | 338p. online resource |
1 Of Mice and Children: Reminiscences of a Teratogeneticist -- 1. Prenatal and Family History -- 2. Childhood -- 3. The Nuclear Family -- 4. School -- 5. University -- 6. Graduate School -- 7. Graduate Studies -- 8. Royal Canadian Air Force -- 9. Medical School -- 10. Getting StartedโMedical Genetics -- 11. Medical Genetics Comes of Age -- 12. Genetic Counseling -- 13. The Teratology Connection -- 14. Cleft Palate and Cortisone -- 15. The Multifactorial/Threshold Model -- 16. The Human Connection -- 17. 6-Aminonicotinamide -- 18. Spin-offs -- 19. Cleft Lip -- 20. Studies in Medical Genetics -- 21. The Terato-Clinical Genetics Dilemma -- 22. The Books -- 23. Travels -- 24. International Conferences on Congenital Malformations -- 25. World Health Organization Committee -- 26. Thalidomide -- 27. Saccharin a Teratogen? -- 28. The Anomalad -- 29. Agent Orange -- 30. Sickle-Cell Screening -- 31. Newfoundland -- 32. Personal History -- References -- 2 The Concept of Homology in Comparative Mammalian Teratology -- 1. Introduction -- 2. Homology -- 3. Concept of Phenotype -- 4. Some Issues in Comparative Pathogenesis -- 5. Homologous Common Congenital Malformations -- 6. Searching for Homologous Congenital Defects -- 7. Do Names and Definitions Matter? -- 8. Some Concluding Thoughts -- References -- 3 Short-Term Methods of Assessing Developmental Toxicity Hazard: Status and Critical Evaluation -- 1. Introduction -- 2. The Drive to Develop New Methods of Detecting Developmental Hazard Potential -- 3. Goals of in Vitro and Alternative Methods in Developmental Toxicology -- 4. Testing Chemicals of Unknown Embryotoxic Activity -- 5. In Vitro Systems Explored for Prescreening Purposes -- 6. Most Frequently Published in Vitro Prescreening Systems -- 7. Assessment of Proposed in Vitro Tests -- 8. Comments on Validation -- 9. Outlook for the Future: Genetic Toxicology versus Developmental Toxicology. Can One Glean Anything from Genetic Toxicology? -- References -- 4 Twinning in Spontaneous Abortions and Developmental Abnormalities -- 1. Introduction -- 2. Types of Twins -- 3. Spontaneous Abortions -- 4. Developmental Abnormalities -- 5. The Vanishing Twin -- 6. Incidence of Twinning -- References -- 5 Experimental Induction of Dominant Mutations in Mammals by Ionizing Radiations and Chemicals -- 1. Introduction -- 2. Gametogenesis -- 3. Review of Results Obtained for Different Endpoints -- 4. Genetic Risk Estimation -- 5. Special Considerations for Future Study of Induction of Dominant Mutations -- References -- 6 The Teratology and Developmental Toxicity of Cadmium -- 1. Introduction -- 2. Cadmium as a Teratogen -- 3. Cadmium and the Chorioallantoic Placenta -- 4. Chronic Exposure to Cadmium during Pregnancy -- 5. Cadmium Exposure in the Perinatal Period -- 6. Summary -- References -- 7 Epidemiologic Aspects of Down Syndrome: Sex Ratio, Incidence, and Recent Impact of Prenatal Diagnosis -- 1. Introduction -- 2. Sex Ratio in Down Syndrome -- 3. Incidence of Down Syndrome and Effects of Demographic Changes -- 4. Effects of Prenatal Diagnosis on Incidence Rates of Down Syndrome -- 5. Concluding Remarks -- References