Title | Bleomycin: Chemical, Biochemical, and Biological Aspects [electronic resource] : Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18-22, 1978 / edited by Sidney M. Hect |
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Imprint | New York, NY : Springer New York, 1979 |
Connect to | http://dx.doi.org/10.1007/978-1-4612-6191-9 |
Descript | XI, 351 p. online resource |
Contentst -- Status Reports -- Summary of the Bleomycin Symposium -- Advances in Bleomycin Studies -- Review of the Structural Studies on Bleomycin -- Synthetic and Biosynthetic Studies -- Studies on the Total Synthesis of Bleomycin -- A Synthetic Approach to the Pyrimidine Moiety of Bleomycin -- Biogenetic Aspects of Bleomycin-Phleomycin Group Antibiotics -- Physical and Spectral Analysis of Bleomycin -- Liquid Chromatography of Bleomycin -- NMR Study of Bleomycin -- Bleomycin as a Metal Chelator -- 1H-NMR Study of the Metal Binding Sites of Bleomycin -- The Metallobleomycins -- Metal Complex of Bleomycinand Its Implication for the Mechanism of Bleomycin Action -- Electron Spin Resonance Studies of 1: 1:1 Bleomycin-Cobalt(II)-Oxygen Adduct Complex -- Interaction of Bleomycin with DNA -- A Role for Iron in the Degradation of DNA -- Contribution of the Superoxide Anion-Hydroxyl Radical Pathway to the Cleavage of DNAby Bleomycin -- Interaction of Bleomycinwith DNA -- A Molecular Basis for the Interaction of Bleomycin with DNA -- Molecular Aspects of Bleomycin-Promoted Damage of Covalently Closed Circular DNA -- The Use of Covalently Closed Circular DNA to Investigate Properties of Bleomycin and Its Analogs -- The Action of Bleomycin on DNA -- Biological Effects of Bleomycin -- Polyamines and the Toxicity of the Bleomycins -- Cytotoxicity of the Various Bleomycins to Cultured Mammalian Cells -- Upward-Concave Dose-Response Relationship in Bleomycin Lethality of Mammalian Cells -- Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine -- Bleomycin-Induced Pulmonary Toxicity: A Model for the Study of Pulmonary Fibrosis -- Concluding Remarks at the Symposium on Bleomycin -- Practical Methods for the Manipulation and Assay of Bleomycin -- A Practical Method for the Separation of Bleomycin Components -- Preparation of Bleomycinic Acid from Bleomycin A2 -- A Practical Method for Preparing Copper-Free Bleomycin A2 -- A Simple Assay for Bleomycin Activity: Degradation of Radioactive DNA to Acid-Soluble Products