Title | Frontiers in Hypertension Research [electronic resource] / edited by John H. Laragh, Fritz R. Bรผhler, Donald W. Seldin |
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Imprint | New York, NY : Springer New York, 1981 |
Connect to | http://dx.doi.org/10.1007/978-1-4612-5899-5 |
Descript | 628 p. online resource |
Frontiers in Hypertension Research: Past, Present and Future Introduction -- Session 1 The Variation in Risk Among Hypertensive Patients: Is the Broad Scale Therapy to Help Only a Few Justifiable? What Pressure Levels Should be Treated? -- Position Paper: The Variation in Risk Among Hypertensive Patients: Is the Broad Scale Therapy to Help Only a Few Justifiable? -- Interpretation of the Hypertension Detection and Follow-Up Program -- Implications of Framingham Data for Treatment of Hypertension: Impact of Other Risk Factors -- Factors Affecting Morbidity and Mortality and the Risk Factor Concept -- Australian Therapeutic Trial in Mild Hypertension -- Treatment of Borderline and Mild Hypertension: The Oslo Study -- Discussion -- Session 2 Dietary Sodium and Human Hypertension -- Position Paper: Dietary Sodium and Human Hypertension -- Sodium Deprivation as an Approach to Hypertension -- Sodium and Other Dietary Factors in Experimental and Human Hypertension: The Japanese Experience -- Metabolic Risks of Diuretic Therapy -- Sodium and Blood Pressure: A New Zealand Study -- Blood Pressure in Sodium Fed Humans -- Adverse Effects of Diuretic Therapy -- Discussion -- Session 3 Sodium Metabolism: The Sodium-Potassium Membrane Pump and Volume Overload Hypertension -- Position Paper: Sodium Metabolism: The Sodium-Potassium Membrane Pump and Volume Overload Hypertension -- Erythrocyte Sodium Extrusion in Primary Hypertension -- Sodium Countertransport and Co-transport in Human Red Cell Membranes -- Cellular Basis of Sodium-Induced Hypertension -- Alteration of Cell Membrane Control over Intracellular Calcium in Essential Hypertension and in Spontaneously Hypertensive Rats -- A Circulating Sodium Transport Inhibitor in Essential Hypertension -- Discussion -- Session 4 Regulation of Blood Pressure by Prostaglandin-Kinin Interactions -- Position Paper: Regulation of Blood Pressure by Prostaglandin-Kinin Interactions -- Prostaglandins in Human Hypertension: Relationships to Renin, Sodium, and Antihypertensive Drug Action -- Interaction of Kinins and Renal Prostaglandins -- Discussion -- Session 5 The Concept of Whole Body Autoregulation and the Dominant Role of the Kidneys for Long-Term Blood Pressure Regulation -- Position Paper: The Concept of Whole Body Autoregulation and the Dominant Role of the Kidneys for Long-Term Blood Pressure Regulation -- Regulation of Renal Blood Flow by Chloride -- Action of Angiotensin II on Renal Blood Flow and Urinary Sodium Excretion -- Neural Regulation of Renal Function -- Renal Perfusion and Vascular Reactivity in Essential Hypertension -- Does Hypertension Develop Through Long-term Autoregulation -- Discussion -- Session 6 Vasoconstriction and Volume Factors in Renovascular Hypertension -- Position Paper: Vasoconstriction and Volume Factors in Renovascular Hypertension -- Intrarenal Resistance in Experimental Benign and Malignant Hypertension -- Renal Mechanisms in the Pathogenesis of Essential Hypertension -- Renal Venous Renin Secretory Patterns Before and After Percutaneous Transluminal Angioplasty: Verification of Analytic Criteria -- Discussion -- Session 7 The Renin-Angiotensin-Aldosterone System for Blood Pressure Regulation and for Subdividing Patients to Reveal and Analyze Different Forms of Hypertension -- Position Paper: The Renin-Angiotensin-Aldosterone System for Blood Pressure Regulation and for Subdividing Patients to Reveal and Analyze Different Forms of Hypertension -- Artifacts in the Diagnosis of Essential Hypertension -- Low Renin Essential Hypertension: Diminution of Aldosterone Suppression? -- Identifying Renin Participation in Hypertensive Patients -- The Renin-angiotensin-aldosterone System in the Maintenance of Blood Pressure -- Discussion -- Session 8 The Control of Renin Release -- Position Paper: The Control of Renin Release -- Humoral Mechanisms of Renin Release -- Intrarenal Renin-angiotensin-sodium Interdependent Renal Vasoconstriction Mechanism Controlling Postclamp Renal Artery Pressure and Renin Release in Chronic One-kidney, One-clip Goldblatt Hypertensive Dog -- Renin Responsiveness to Neural and Nonneural Mediated Stimuli in the Renin Subgroups of Essential Hypertension -- Alpha and Beta Adrenoreceptors and Renin Release -- Discussion -- Session 9 Plasma Prorenin -- Position Paper: Plasma Prorenin -- Renin Purification -- High Molecular-weight Form of Renal Renin and Renin-binding Substance in the Dog -- Brain Renin -- Role of the Brain renin-angiotensin System in Central Mechanisms of Blood Pressure Control -- Vascular Renin -- Discussion -- Session 10 The Sympathetic Nervous System and Hypertension -- Position Paper: The Sympathetic Nervous System and Hypertension -- Effect of Posture, Isometric Hand-grip Exercise and Norepinephrine Infusion in Normal Renin Hypertensive Patients -- Interrelationships between Plasma Norepinephrine and Blood Pressure Response to Norepinephrine Normotension and Hypertension -- Central Noradrenergic Mechanisms in Hypertension: and in Postural Hypertension -- Use of Circulating Catecholamines for the Detection of Autonomic Abnormalities in Human Hypertension -- Sympathetic Nervous System, Catecholamine Receptors, and Hypertension -- Changing Role of Beta- and Alpha-adrenoreceptor-mediated Cardiovascular Responses in the Transition from High-cardiac Output into a High-peripheral Resistance Phase in Essential Hypertension -- Discussion -- Session 11 The Brain, Centrally Acting Drugs, the Renin System and Blood Pressure Regulation -- Position Paper: The Brain, Centrally Acting Drugs, the Renin System and Blood Pressure Regulation -- Sodium and Central Nervous System Mechanisms -- Experimental Evidence in Support of a Central Neural Imbalance Hypothesis of Hypertension -- Brain Centers for Pharmacologic Control of the Cardiovascular System -- Central and Peripheral Alpha-adrenoreceptors and the Actions of Clonidine and Methyldopa -- Discussion -- Session 12 Hypertension Mechanisms in Experimental Animals and Their Relevance to Humans -- Position Paper: Hypertension Mechanisms in Experimental Animals and Their Relevance to Humans -- Neurogenic Elements in Rat Primary Hypertension: Differences between Spontaneously Hypertensive Rats and the Milan Hypertensive Strain -- Hypertension and Stroke Mechanisms in Spontaneously Hypertensive Rats -- Pressor and Volume Effects of Vasopressin -- Session 13 Hypertension, Vasopressors, and the Susceptibility to Vascular Injury -- Position Paper: Hypertension, Vasoconstriction, and the Causation of Cardiovascular Injury: The Renin-Sodium Profile as an Indicator of Risk -- Vascular Compliance and Pulsatile Flow as Determinants of Vascular Injury -- Endothelial Damage in Hypertension -- Hypertension Induced Vascular Fibrosis and its Reversal by Antihypertensive Drugs -- Hypertension, Vasopressors and the Susceptibility to Vascular Injury: Experimental and Clinical Studies -- Discussion -- Session 14 Antihypertensive Actions of Beta Blockers -- Position Paper: Antihypertensive Actions of Beta Blockers -- Comparison of a Beta-blocker and Converting Enzyme Inhibitor in Two Types of Experimental Hypertension -- Pressor Effect of Beta-adrenergic Blockade and Angiotensin II in Nephrectomized Rats -- Catecholamines as Predictors of Drug Response -- Renin Activity and the Response to Beta-blockade -- Total Peripheral Resistance and Beta-adrenergic Blockade -- Mechanisms of Beta-blockade Hypotension -- Aldosterone: Possible Roles in Sustaining Essential Hypertension and in Determining Response to Antihypertensive Treatment -- Discussion -- Session 15A Differential Features of Beta Adrenoreceptor Blocking Drugs for Therapy -- Position Paper: Differential Features of Beta Adrenoreceptor Blocking Drugs for Therapy -- Session 15B Potentials for Secondary Cardioprotection in Clinical Trials -- Postinfarction Intervention Studies with Propranolol and Atenolol: Problems in Design and Interpretation -- Secondary Prevention of Myocardial Infarction with Beta-adrenoreceptor Blocking DrugsโAlprenolol, Practolol and Oxprenolol -- The Role of Beta Blockers in Cardioprotection -- Discussion -- Session 16 Converting Enzyme Blockade as a Therapeutic Modality -- Position Paper: Angiotensin-Converting Enzyme Blockade as a Therapeutic Modality -- Immediate and Delayed Antihypertensive Effects of Angiotensin-Converting Enzyme Inhibition with Captopril -- Late Resistance to Captopril -- Converting Enzyme Inhibitors in the Treatment of Heart Failure -- Summary of Worldwide Captopril Experience in Patients with Severe, Treatment-resistant Hypertension -- The Effect of Captopril on Urinary Kinins and Urinary Kallikrein Activity in Essential Hypertension -- Session 17 Physiologic Effects and Diagnostic Relevance of Acute Converting Enzyme Blockade -- Position Paper: Physiologic Effects and Diagnostic Relevance of Acute Converting Enzyme Blockade -- Does Captopril Decrease Blood Pressure by Mechanisms Other Than Inhibition of Angiotensin II Formation -- The Effects of Intravenous Angiotensin II on the Cardiac Baroreceptor Reflex -- Captopril in Angiotensin-salt Hypertension: A Possible Linkage between Angiotensin, Salt, Vascular Disease and Renomedullary Interstitial Cells -- Effect of Converting Enzyme Inhibition with Teprotide on Hemodynamics and Cardiovascular Reflexes in Normotensive Subjects -- Discussion -- Session 18 New Approaches to Renin System Blockade -- Position Paper: New Approaches to Renin System Blockade -- Studies on Experimental Hypertension Using Blockers of Renin, Converting Enzyme and Angiotensin II -- Active-site Specific Inhibitors of Angiotensin-Converting Enzyme -- Regulation and Properties of Adrenal and Vascular AII Receptors -- Discussion -- Epilogue: After Dinner Science and Friendship -- Opening Remarks -- Percutaneous Transluminal Dilatation of Renal Artery Stenosis -- Closing Remarks