1 The T Cell Antigen Receptor: Structural and Functional Considerations -- 1. Overview -- 2. Functional and Physical Analysis of T Cell Antigen-Specific Receptors -- 3. Serological and Biochemical Analysis of T Cell Antigen-Specific Receptors -- 4. Physiologic Constraints in the Recognition Function of the T Cell Antigen Receptor -- 5. Cytotoxic T Cell Ligand-Binding Sites are Critically Affected by Recognition Structures on Other Cells -- 6. Summary -- References -- 2 Regulation of the Immune Response -- 1. Introduction -- 2. Ir Genes in Guinea Pigs -- 3. The Ir-1 Gene -- 4. Genetic Control of Immune Responsiveness to Staphylococcal Nuclease -- 5. Ia Antigens -- 6. Complementing Ir Genes -- 7. Immunosuppressor Genes -- 8. Genetic Control of Cellular Immune Responses -- 9. Human Immune-Response Genes -- 10. An Hypothesis to Explain the Interrelationship Among Ir Genes, Ia Antigens, and MLR-Stimulating Determinants -- 11. Conclusions -- References -- 3 Immunosuppressive Agents: A Conceptual Overview of Their Action on Inductive and Regulatory Pathways -- 1. Introduction -- 2. Inductive and Regulatory Aspects of Immune Responses: Current Concepts -- 3. Classes and Subclasses of Lymphocytes and Their Functions -- 4. Antibody Responses to Thymus-Independent and Thymus-Dependent Antigens -- 5. Inductive and Regulatory Functions: Antigens, Cells, Cognitive and Regulating Molecules, and Networks -- 6. A Closer Look at Induction and Regulation of Cell-Mediated Immunity -- Acknowledgments -- References -- 4 Immunosuppressive Agentsโ{128}{148}Their Action on Inductive and Regulatory Pathways: The Differential Effects of Agents Used Clinically or Experimentally in the Treatment of Cancer -- 1. Variables that Determine the Effect of Cancer Therapeutic Agents on Antibody Production -- 2. Diversity of Effects of Immunosuppressive Drugs on CMI -- 3. Alkylating Agents Exert Selective Action Against Cells in the Suppressor Pathway -- 4. A Closer Look at Agents That Are More Suppressive Before Immunization -- 5. The Many Faces and Interfaces of Cyclophosphamide Action -- Acknowledgments -- References -- 5 The Immunobiology of Human Non-Hodgkinโ{128}{153}s Lymphomas -- 1. Introduction -- 2. Classification Schema -- 3. Functional Studies -- 4. The Ontogeny of Lymphocytes -- 5. Overview of Immunoregulation -- 6. Lymphocyte Identification -- 7. New Directions -- Acknowledgments -- References -- 6 Cell-Mediated Immunity in Autoimmune Disease -- 1. Introduction -- 2. Self-Recognition and Tolerance -- 3. Induction of Autoimmunity -- 4. Pathogenic Mechanisms in Autoimmune Disease -- 5. Cell-Mediated Immunity in Autoimmune Diseases of Animals -- 6. Cell-Mediated Immunity in Autoimmune Disease of Humans -- 7. Summary -- References -- 7 Cell-Mediated Immunity in Tumor Rejection -- 1. Immune Surveillanceโ{128}{148}A Theory Under Scrutiny -- 2. Tumor Antigens -- 3. Effector Mechanisms in Cell-Mediated Immunity -- 4. Effector Molecules -- 5. Depression of Immunity by Tumors: Suppressor Cells and Factors -- 6. Immunotherapy -- 7. Conclusions -- References -- 8 Transfer Factor and Other Factors in Leukocyte Dialyzates That Affect Cell-Mediated Immunity -- 1. Introduction -- 2. The Transfer Phenomenon -- 3. Clinical Use of Leukocyte Dialyzates or Transfer-Factor Preparations -- 4. Biochemical Characterization -- 5. Experimental Considerations -- 6. Implications for Immunotherapy -- References -- 9 Hybridization of Lymphocytes: Techniques and Applications -- 1. Introduction -- 2. B Cell Hybrids -- 3. T Cell Hybrids -- 4. Applications and Future Perspectives -- Notes Added in Proof -- Acknowledgment -- References -- 10 Immunologic Tests for Diagnosis and Monitoring of Defects in Cell-Mediated Immunity -- 1. Introduction -- 2. Anatomy of the Immune System -- 3. In Vivo Manifestations of Cell-Mediated Immunity -- 4. In Vitro Tests of Cell-Mediated Immunity -- 5. Clinical Immunodeficiencies -- 6. Conclusion -- Acknowledgments -- References