Title | Hormone Resistance and Other Endocrine Paradoxes [electronic resource] / edited by Margo Panush Cohen, Piero P. Foร |
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Imprint | New York, NY : Springer New York, 1987 |
Connect to | http://dx.doi.org/10.1007/978-1-4612-4758-6 |
Descript | XII, 271 p. online resource |
1. Introduction: The Journey of the Endocrine Signal: A Paradigm of Murphyโs Law -- I. Chemical Control of Morphogenesis -- II. Hormone Biosynthesis -- III. Hormone Storage and Release -- IV. Hormone Transport -- V. Hormone Binding and Recognition -- VI. Transduction of the Endocrine Signal -- VII. Extinction of the Endocrine Signal -- VIII. Drug-Induced Changes of the Endocrine Signal -- IX. Summary -- 2. Insulin Gene Mutations and Abnormal Products of the Human Insulin Gene -- I. Insulin Biosynthesis -- II. Abnormal Insulin Gene Products -- III. Structure-Function Relationships and Biological Activity -- IV. Clinical Relevance -- V. Summary and Perspectives -- 3. Euthyroid Hyperthyroxinemia -- I. Binding Abnormalities -- II. Hormone Resistance Syndromes -- III. Nonthyroidal Illness -- IV. Drugs -- V. Exogenous T4 Administration -- VI. High Altitude -- VII. Summary -- 4. Pseudohypoparathyroidism: Target Organ Resistance to Parathyroid Hormone and Other Metabolie Defects -- I. A Selective Historical Review -- II. Classification -- III. Pathogenesis -- IV. Function of Other Endocrine Systems in PsHP -- V. Genetics of PsHP -- VI. Treatment of PsHP -- 5. Syndromes of Vitamin D Resistance -- I. Vitamin D Metabolism -- II. Vitamin D Physiology -- III. Hormone Action -- IV. Vitamin D and Elemental Deficiency -- V. Phosphate-Wasting Syndromes -- VI. Vitamin DโDependent Rickets -- VII. Summary -- 6. Androgen Insensitivity Syndromes: Paradox of Phenotypic Feminization with Male Genotype and Normal Testicular Androgen Secretion -- I. Historical Considerations -- II. Normal Androgen Physiology -- III. Classification of Male Pseudohermaphroditism -- IV. Molecular Mechanisms of Androgen Action in Target Cells -- V. Clinical Syndrome of 5?-Reductase Deficiency -- VI. Androgen Receptor and Postreceptor Defects -- VII. Concluding Remarks -- 7. States of Aldosterone Deficiency or Pseudodeficiency -- I. Physiologic Effects of Mineralocorticoid Hormones -- II. Syndromes of Aldosterone Deficiency and Pseudodeficiency -- 8. Bartterโs Syndrome -- I. Case Summaries -- II. Historical Perspective -- III. Etiology and Pathophysiology -- IV. Differential Diagnosis -- V. Clinical Evaluation -- VI. Treatment -- VII. Analysis of Cases