I. Pathological Basis of Therapy in Alzheimerโ{128}{153}s Disease -- Criteria for the Diagnosis of Alzheimerโ{128}{153}s Disease -- Neuropathology Of Alzheimerโ{128}{153}s Disease -- Processing of Amyloid, Cytoskeletal Damage and Apolipoproteins -- Cell Death: Excitotoxins, Apoptosis And Hypometabolism -- Neurotrophins, Growth Factors and Neuroprotectors -- Animal Models -- II. The Cholinergic System in Brain -- Treatment of Alzheimer Disease -- Cholinesterase Inhibitors in Alzheimer Disease Treatment -- III. Nicotinic and Muscarinic Cholinergic Agonists -- Nicotinic Agonists -- Muscarinic Agonists and Antagonists -- The Potential of Antioxidant Therapy -- The Potential for Anti-Inflammatory Therapy -- IV. Development of New Therapies in Alzheimer Disease -- Design of Clinical Trials -- Advances in Assessment -- SPECT and PET -- Potential Markers of Disease Progression and Drug Efficacy in Alzheimerโ{128}{153}s Disease -- Treatment of Behavioral and Psychosocial Disturbances -- V. Social Issue in Alzheimer Disease -- Legal and Ethical Issues -- Socio-Economic As pects of Alzheimer Disease Treatment -- International Harmonization of Drug Guidelines -- Research Priorities in Alzheimer Disease Treatment โ{128}{148} An International Perspective -- Author Index