Title | Thrombopoiesis and Thrombopoietins [electronic resource] : Molecular, Cellular, Preclinical, and Clinical Biology / edited by David J. Kuter, Pamela Hunt, William Sheridan, Dorothea Zucker-Franklin |
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Imprint | Totowa, NJ : Humana Press, 1997 |
Connect to | http://dx.doi.org/10.1007/978-1-4612-3958-1 |
Descript | XVIII, 412 p. online resource |
I: Introduction -- 1 Megakaryocyte Biology -- 2 Platelet Structure and Function -- 3 The Evolution of Mammalian Platelets -- 4 Potential Clinical Applications of Thrombopoietic Growth Factors -- II: The Search for the Physiologic Regulator of Platelet Production -- 5 Historical Perspective and Overview -- 6 The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl -- 7 Mpl Expression and Functional Role in Human Megakaryocytopoiesis -- 8 The Purification and Cloning of Human Thrombopoietin -- 9 The Purification of Thrombopoietin from Thrombocytopenic Plasma -- 10 The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis -- III: Molecular Biology -- 11 Structure of Thrombopoietin and the Thrombopoietin Gene -- 12 Transcription Factors in Megakaryocyte Differentiation and Gene Expression -- 13 The Biological Significance of Truncated and Full-Length Forms of Mpl Ligands -- IV: Cellular Biology -- 14 In Vitro Effects of Mpl Ligand on Human Hemopoietic Progenitor Cells -- 15 Effect of Cytokines on the Development of Megakaryocytes and Platelets: An Ultrastructural Analysis -- 16 The Thrombopoietin Receptor, Mpl, and Signal Transduction -- 17 Regulation of Proplatelet and Platelet Formation In Vitro -- 18 In Vitro Effects of Mpl Ligands on Platelet Function -- V: Preclinical Biology -- 19 In Vivo DoseโResponse Effects of Mpl Ligands on Platelet Production and Function -- 20 Efficacy of Mpl Ligands and other Thrombopoietic Cytokines in Animal Models -- 21 Genetic Manipulation of Mpl Ligand and Thrombopoietin In Vivo -- VI: Clinical Biology -- 22 Serum Levels of Thrombopoietin in Health and Disease -- 23 The Regulation of Platelet Production In Vivo