Title | Autoimmunity and the Pathogenesis of Diabetes [electronic resource] / edited by Fredda Ginsberg-Fellner, Robert C. McEvoy |
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Imprint | New York, NY : Springer New York, 1990 |
Connect to | http://dx.doi.org/10.1007/978-1-4612-3218-6 |
Descript | XII, 296 p. online resource |
1. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present -- Autoimmunity -- The Concept of IDDM as an Autoimmune Disease -- The Association Between IDDM and HLA -- Etiologic Factors with Implications for the Pathogenesis of IDDM -- The Autoantigen in IDDM -- Presentation of Autoantigen -- Autoantigen Recognition in IDDM -- The Effector Phase in IDDM -- Conclusion -- 2. Immunogenetics and the Pathogenesis of Insulin-Dependent Diabetes Mellitus -- Genetic Background -- Environmental Factors -- Speculations on the Mechanism of IDDM Pathogenesis -- 3. Association of Insulin-Dependent Diabetes Mellitus and Other Autoimmune Diseases -- IDDM and Thyroid Autoimmunity -- Other Endocrinopathies Associated with Type 1 Diabetes Mellitus -- How Does Autoimmune Disease Develop? -- Can Autoantibodies Affect More Than One Gland? Are They Mono- or Polyclonal? -- Summary and Conclusions -- 4. The Humoral Anti-Islet Immune Response: Cytoplasmic Islet-Cell Antibodies: Technical Aspects and Clinical Applications -- Assays for ICA Determination -- Approaching Standardization of the Cytoplasmic ICA Test -- Clinical Application of the ICA Test -- Synopsis, Recommendations, and Conclusions -- 5. The Humoral Anti-Islet Response: Biochemical Characterization -- Autoantigens Detected in Human Islets -- Autoantigens May Define Disease Specificity in Human Autoimmunity -- Western Blotting Analysis of Islet Autoantigens -- Analyzing Circulating Immune Complexes in Diabetes -- Summary -- 6. The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens -- What Are Gangliosides? -- Immunochemical Characterization of Monoclonal Antibody-Defined, Islet-Cell Antigens -- Immunochemical Properties of the Autoantigen(s) of Pancreatic Islets -- Extraction and Partial Purification of the ICA Glycolipid Antigen -- Glycolipid Antigens in Animal Models of Type I Diabetes -- Multiplicity of Antigens in Humoral Autoimmunity of Type I Diabetes -- Monoclonal Antibody-Defined, Islet-Cell Glycolipid Antigens -- Physiological Roles of Islet-Cell Gangliosides -- Antibodies to Glycolipids in Diseases Other than Type I Diabetes Mellitus -- Immunogenicity of Glycolipids -- T-Cell Reactivity to Glycolipid Antigens -- Final Comments -- 7. Insulin Autoantibodies -- 8. Cell-Mediated Anti-IsletโCell Immune Response: Clinical Experience and Lessons from Animal Models -- Cell-Mediated, Anti-BetaโCell Autoimmunity in Human Diabetes -- Diabetes Induced by Multiple, Subdiabetogenic Doses of Streptozotocin -- Diabetes in the Bio-Breeding Rat -- Diabetes in Nonobese Diabetic Mice -- Summary and Conclusions -- 9. The Pathogenesis of Immunologically Mediated Diabetes -- Mechanism of the Disease Process -- Disease Recurrence Model -- Disease Recurrence in Islet Grafts is CD4 T-Cell Dependent -- Free Radical Involvement in the Disease Process -- Disease Recurrence in the Grafted Tissue: A Summary -- Lessons from Fetal Pancreas Transplantation -- Effect of Cyclosporine on Disease Recurrence -- 10. Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus -- Direct Cytolytic Viral Infection of Beta-Cells -- Association of Virus Infection with Autoimmune IDDM -- Persistent Infection of Pancreatic Beta-Cells and Mild Hyperglycemia -- Conclusion -- 11. Immune Intervention in Diabetes: State of the Art and Future Directions -- Experimental Immunotherapy in IDDM of Recent Onset -- Open Studies of Immunomodulatory Therapies in IDDM -- Randomized Control Trials of the Effects of Cyclosporin in IDDM -- Efficacy and Safety of Immunosuppression in Remission Induction in IDDM -- Timing of Immunomodulatory Interventions in IDDM -- IDDM in Remission: Endocrine Metabolic Status and Its Possible Implications -- Strategies for Continuing Studies of Immunotherapy in IDDM -- Summary and Conclusions