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TitleCell Death and Diseases of the Nervous System [electronic resource] / edited by Vassilis E. Koliatsos, Rajiv R. Ratan
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 1999
Connect tohttp://dx.doi.org/10.1007/978-1-4612-1602-5
Descript XXI, 683 p. online resource

SUMMARY

Written by pioneers in the field, Cell Death and Diseases of the Nervous System captures all the important classic and new research on neuronal injury and cell death and the application of these results to the treatment of a wide range of neurological and neuropsychiatric illness. The outcome is a unique integration of cellular and molecular insights, clinical knowledge, and therapeutic experience. As the chapters move back and forth from the basic to the clinical level, exciting possibilities emerge for finding therapeutic approaches to neurological illness based on a new understanding of fundamental processes. Extensive cross-referencing allows easy navigation between chapters and different points of view. Cell Death and Diseases of the Nervous System provides a concise summary of current neurological knowledge from the perspective of the basic disease mechanisms involved in neuronal injury and death. In an era of increasing specialization, this book offers an authoritative integration and unique cross-fertilization for all those seeking to better understand and treat neurological illness


CONTENT

I. Definitionsโ{128}{148}Cellular and Molecular Mechanisms -- 1. Apoptosis Versus Necrosis: How Valid a Dichotomy for Neurons? -- 2. Asynchronous Death as a Characteristic Feature of Apoptosis -- 3. Free Radicals and Mitochondria Dysfunction in Excitotoxicity and Neurodegenerative Disease -- 4. Calcium and Cell Death -- 5. Proteases: Critical Mediators of Apoptosis -- 6. The Cell Cycle and Neuronal Cell Death -- II. Animal Models -- 7. Neuronal Cell Death in C. elegans -- 8. Cellular Interactions that Regulate Programmed Cell Death in the Developing Vertebrate Nervous System -- 9. Axotomy-Induced Motor Neuron Death -- 10. Excitotoxic Cell Death -- 11. Neurotoxins and Neuronal Death:An Animal Model of Excitotoxicity -- III. Nerve Cell Death in Human Diseases -- 12. DNA Repair and Neurological Diseases -- 13. Cell Death and the Mitochondrial Encephalomyopathies -- 14. Viral Encephalitis -- 15. Mechanisms of Cell Injury in Prion Diseases -- 16. Blood Flow, Energy Failure, and Vulnerability to Stroke -- 17. Epilepsy and Cell Death -- 18. Trauma to the Nervous System -- 19. Approaches to the Study of Diseases Involving Oligodendroglial Death -- 20. Motor Neuron Disease -- 21. Cerebellar Degenerations -- 22. Parkinsonโ{128}{153}s Disease -- 23. Huntingtonโ{128}{153}s Disease and DRPLA: Two Glutamine Repeat Diseases -- 24. Cortical Destruction and Cell Death in Alzheimerโ{128}{153}s Disease -- 25. HIV-1 Infection of the CNS: Evidence for Apoptosis of Nerve Cells -- 26. Neurotoxicity of Drugs of Abuse -- 27. Schizophrenia -- IV. Approaches in Treating Nerve Cell Death -- 28. Trophic Factors as Therapeutic Agents for Diseases Characterized by Neuronal Death -- 29. Early Experiences with Trophic Factors as Drugs for Neurological Disease: Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor for ALS -- 30. Approaches in Treating Nerve Cell Death with Calcium Chelators -- 31. Antiglutamate Therapies for Neurodegenerative Disease: The Case of Amyotrophic Lateral Sclerosis -- 32. Antioxidants and the Treatment of Neurological Disease


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