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TitleBiochemistry of Pulmonary Emphysema [electronic resource] / edited by C. Grassi, J. Travis, L. Casali, M. Luisetti
ImprintLondon : Springer London : Imprint: Springer, 1992
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Descript XV, 200 p. 13 illus. online resource


Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy


From the Contents: Pulmonary Emphysema: What's going on -- Elastin and the Lung -- An Introduction to the Endopeptidases -- Lung Proteinase and Emphysema -- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes -- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates -- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances -- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung -- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema -- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy -- Neutrophils, Neutrophil Elastase and the Fragile Lung

Medicine Pharmacology Respiratory organs -- Diseases Rehabilitation Biochemistry Medicine & Public Health Rehabilitation Pneumology/Respiratory System Biochemistry general Pharmacology/Toxicology


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