Title	Biochemistry of Pulmonary Emphysema [electronic resource] / edited by C. Grassi, J. Travis, L. Casali, M. Luisetti
Imprint	London : Springer London : Imprint: Springer, 1992
Connect to	http://dx.doi.org/10.1007/978-1-4471-3771-9
Descript	XV, 200 p. 13 illus. online resource

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy

From the Contents: Pulmonary Emphysema: What's going on -- Elastin and the Lung -- An Introduction to the Endopeptidases -- Lung Proteinase and Emphysema -- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes -- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates -- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances -- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung -- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema -- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy -- Neutrophils, Neutrophil Elastase and the Fragile Lung