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AuthorUnderwood, J. C. E. author
TitleIntroduction to Biopsy Interpretation and Surgical Pathology [electronic resource] / by J. C. E. Underwood
ImprintLondon : Springer London, 1981
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This book is primarily addressed to the needs of the trainee histopathologist. It is intended to bridge that gap between the descriptive histopathology taught as part of the undergraduate medical curriculum and the interpretative skills required of the diagnostician. My object is to convey the basic general principles, in theory and practice. Books are, however, only adjuncts to practical experience and not substitutes for it. Indeed, to obtain the maximum benefit from this book it is essential that the reader is actively involved in the work of a diagnostic laboratory. Only in this way can the trainee become thoroughly conversant with the rudiments of biopsy interpretation. To retain detailed knowledge of the histological appearances of the plethora of diseases and their permutations to which humans are subject is beyond the mental resources of most individuals. For this reason, histopathologists probably refer to books more often than do most other specialists. This book aims to provide a core of knowledge sufficient to master the fundamental aspects, while still encouraging the intelligent use of all those indispensable atlases, monographs, and fascicles for which there is no substitute


1 Diagnostic Histopathology -- A. Origins of Histopathology -- B. The Objectives of Histopathology -- C. The Histopathological Diagnosis -- 2 Macroscopy, Microscopy, and Sampling -- A. Sampling Error -- B. Sampling Biopsies and Surgical Resections -- C. Specific Types of Biopsy -- D. Imprints, Smears, and Squashes -- E. Living Cells -- F. Specimen Radiology -- G. Section Thickness -- H. Information and Magnification -- 3 The Use of Stains -- A. Principles of Staining -- B. Indications for Special Stains -- C. Immunofluorescence and Immunohistochemistry -- D. Identification of Specific Substances and Cells -- E. Autoradiography -- 4 Interpretation of Histological Appearances -- A. Artifact of Sections -- B. Basic Microscopy -- C. Methods of Interpretation -- D. Morphology of Disease Processes -- 5 Borderline Lesions, Pseudomalignancy, and Mimicry -- A. Borderline Lesions -- B. Mimicry of Histological Features -- C. Pseudomalignancy and Related Diagnostic Problems -- 6 Rapid Frozen Section Diagnosis -- A. Clinical Indications -- B. Methods -- C. Interpretation -- D. Common Applications -- E. Reliability -- 7 Diagnostic Electron Microscopy -- A. Principles of Transmission Electron Microscopy -- B. Diagnostic Value of Transmission Electron Microscopy -- C. Scanning Electron Microscopy -- D. X-ray Microanalysis -- 8 Quantitative Methods -- A. Stereological Principles -- B. Stereological Methods -- C. Automatic and Semi-Automatic Image Analysis -- D. Microspectrophotometry and Flow Microfluorimetry -- E. Practical Applications -- 9 Reporting and Classification of Biopsy Diagnoses -- A. The Biopsy Report -- B. Disease Classifications -- C. Data Storage and Retrieval -- D. Clinical Assimilation

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