Title | Platelet Heterogeneity [electronic resource] : Biology and Pathology / edited by John Martin, Anthony Trowbridge |
---|---|
Imprint | London : Springer London, 1990 |
Connect to | http://dx.doi.org/10.1007/978-1-4471-1763-6 |
Descript | XVII, 270p. 78 illus. online resource |
1 Platelet Density, Heterogeneity and Platelet Ageing -- Experimental Models Used to Examine the Significance of Platelet Heterogeneity -- Potential Problems Associated with Various Experimental Models -- Ultrastructural Studies and Platelet Heterogeneity -- Density-Dependent Platelet Properties and Platelet Heterogeneity -- Kinetic Models to Examine the Relationship Between Platelet Density and Age -- Is Heterogeneity of Density-Dependent Platelet Properties Significant? -- Contributions of Events During Thrombopoiesis to Platelet Heterogeneity -- Conclusions -- References -- Technical Questions -- 2 The Biology of Platelet Volume Heterogeneity -- Characteristics of Size-Dependent Platelet Subpopulations -- Relationship of Platelet Size to Platelet Age -- The Relationship of the Mean Platelet Volume to the Platelet Count -- Summary -- References -- Technical Questions -- 3 Is Platelet Heterogeneity Due to Ageing or Thrombopoiesis? -- Method of Separation of Platelets on Stractan Density Gradients -- Types of Experiments -- Recovery of Ability of Platelets to Synthesize Thromboxane After Aspirin Administration -- Conclusions About the Relation Between Density and Survival of Rabbit Platelets -- Do Discontinuous Gradients Introduce Artefacts? -- Differences Between Most Dense and Least Dense Platelet Subpopulations -- Effect of Aggregating and Release-Inducing Agents on Platelet Density -- Effect on Density of Raising the Concentration of Cyclic AMP in Rabbit Platelets -- Changes in Density In Vivo -- Conclusions -- References -- Technical Questions -- Discussion (Chapters 1โ3) -- 4 Origins and Significance of Platelet Heterogeneity in a Non-human Primate Model -- Platelet Density -- Characterization of Young Platelets -- Chronic Thrombocytopenia -- Acquired Platelet Alterations -- Conclusions -- References -- 5 Platelet Formation, Platelet Density and Platelet Ageing -- The Proplatelet Theory of Platelet Formation -- Platelet Density Heterogeneity and Platelet Ageing -- Conclusions -- References -- 6 Characterization of Platelets and Megakaryocytes of the Wistar Furth Rat: An Animal Model with Inherently Large Mean Platelet Volume -- Materials and Methods -- Results -- Discussion -- References -- Technical Questions -- 7 The Circulating Megakaryocyte, Platelet Volume Heterogeneity and Thrombopoiesis -- The Concept of Bone Marrow Thrombopoiesis: How Did It Start? -- The Megakaryocyte Demarcation Membrane System and Platelet Territories -- Diapedesis and Sinusoidal Megakaryocytes -- Circulating Megakaryocytes -- Pulmonary Megakaryocytes -- Platelet Volume Heterogeneity -- Pulmonary Thrombopoiesis: A Simple Mechanism -- Conclusions -- References -- 8 The Genesis of Platelet Volume and Density Distributions -- Platelet Size Distributions From Normal Subjects Approximate Log-normality -- Circulating Platelet Populations of Widely Different Age Distributions Approximate Log-normality -- Platelet Volume Can Be Regulated -- Platelet Volume Is Inversely Correlated to Platelet Count -- Platelet Volume and Density Are Partially Correlated -- Platelet Function Is Linked to Platelet Size and Density -- Megakaryocyte Ploidy Heterogeneity Cannot Explain Log-normality -- Fragmentation and Growth of Megakaryocyte Cytoplasm Are Major Determinants of Platelet Size -- References -- Discussion (Chapters 7 and 8) -- 9 Platelet Heterogeneity in Vascular Disease -- The Origin of Platelet Heterogeneity -- Normal Physiological Response to Change in Platelet Destruction -- The Control of Platelet Production -- Platelet Volume in Myocardial Infarction -- The Bleeding Time in Myocardial Infarction -- Platelet Volume and Megakaryocytes in Animal Models of Vascular Disease -- Conclusions -- References -- Technical Questions -- 10 The Heterogeneity of Platelets -- References -- Technical Questions -- General Discussion -- 11 Summing Up: Platelet Heterogeneity: Biology and Pathology -- Bone Marrow and Thrombopoiesis -- References -- Discussion -- 12 Chairmanโs Commentary -- Technical Questions -- Basic Questions