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AuthorMoyes, Judy S. E. author
TitleNeuroblastoma [electronic resource] : mIBG in its Diagnosis and Management / by Judy S. E. Moyes, V. Ralph McCready, Ann C. Fullbrook
ImprintLondon : Springer London, 1989
Connect tohttp://dx.doi.org/10.1007/978-1-4471-1674-5
Descript VIII, 168p. 241 illus. online resource

CONTENT

1 An Overview of Neuroblastoma -- Pathology -- Clinical Features -- Diagnostic Features -- Clinical Staging -- Prognostic Features -- Treatment -- 2 Chemistry and Pharmacy of mIBG -- Pharmacology -- Radiolabelled mIBG Products -- Formulations and Stability of mIBG -- Toxicology -- 3 Techniques for Imaging with mIBG -- Patient Preparation -- Radiopharmaceuticals -- Gamma Camera Technique -- Administration of mIBG -- Planar Imaging -- Single-photon Emission Computed Tomography -- Hard Copy -- 4 The Normal Pattern of Distribution of mIBG in Children with a History of Cancer -- Normal Distribution -- The Thyroid Gland -- The Adrenal Gland -- The Liver -- The Spleen -- The Kidneys and Bladder -- The Gastrointestinal Tract -- The Lung -- The Heart -- The Salivary Glands, Nasopharynx and Lacrimal Glands -- The Bone Marrow -- Bone -- Normal mIBG Studies in Children of Different Ages -- 5 Case Studies with Abnormal Uptake of mIBG -- 6 Radiation Dosimetry of Radioiodine-Labelled mIBG -- Review of Radionuclide Dosimetry -- The Physical Properties of 123I and 131I -- Calculation of Absorbed Dose in Children -- 7 Practical Aspects of Targetted Radiotherapy with mIBG -- General Principles -- Principles of Therapy with mIBG -- Selection of Patients for mIBG Therapy -- The mIBG Therapy Room -- Patient Investigations Before Treatment -- Drugs which Interfere with mIBG Uptake -- Thyroid Blockade -- Selection of Activity of mIBG to Administer -- Sedation of Patients During Therapy -- Practical Considerations During Administration of mIBG -- Radiation Protection Guidelines -- Discharge after mIBG Therapy -- Appendices -- Appendix A: OPEC Chemotherapy -- Appendix B: High-Dose Melphalan followed by Autologous Bone Marrow Rescue -- Appendix C: Sedation for Children Undergoing mIBG Scintigraphy -- Appendix D: Thyroid Gland Blockade for mIBG Scintigraphy and Targetted Radiotherapy -- Appendix E: Drugs which Interfere with mIBG Studies -- Appendix F: Modified OPEC Chemotherapy


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