Title | Platelet-Vessel Wall Interactions [electronic resource] / edited by R. Michael Pittilo, Samuel J. Machin |
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Imprint | London : Springer London, 1988 |
Connect to | http://dx.doi.org/10.1007/978-1-4471-1455-0 |
Descript | XIV, 198p. 55 illus. online resource |
1 The Platelet -- Morphology -- Platelet Function -- Biochemistry -- Platelet Coagulant Activity -- 2 Endothelium and the Vessel Wall -- General Introduction -- General Structure of the Vessel Wall -- Vascular Endothelium -- Endothelial Permeability -- Synthetic and Metabolic Functions -- Endothelial Regeneration -- Endothelial Injury -- 3 The Use of Cultured Endothelial Cells in the Study of Platelet-Vessel Wall Interactions -- The Culturing of Vascular Endothelial Cells -- Growth Factors -- Extracellular Matrix Proteins -- Arachidonic Acid Metabolism -- In Vitro Assessment of Platelet Interaction with the VesselWall -- Assessment of Cytotoxicity using Cultured Endothelial Cells -- The Effect of Nicotine on Endothelial Cells -- Conclusion -- 4 Smoking and Platelet-Vessel Wall Interactions -- The Effects of Cigarette Smoke, Carbon Monoxide and Nicotine on Endothelial Morphology and Platelet-Endothelial Cell Interactions -- Cigarette Smoking and Platelet Aggregation -- Cigarette Smoking and Endothelial Cell Prostacyclin Production -- Novel Methods for Studying the Effects of Cigarette Smoking on Endothelium and Platelets -- Conclusions -- 5 Mesothelium as a Non-thrombogenic Surface -- Embryology -- Morphology -- Function -- Mesothelium as an Endothelium Substitute -- 6 Platelet-Endothelial Interactions in Renal Injury -- I. Potential Role for Platelets in Mediating Renal Injury -- to Renal Injury -- Evidence for Platelet Involvement in Glomerular Injury in Man -- How Platelets may Contribute to Renal Injury -- Mechanisms of Platelet Activation -- Role of Platelets in Experimental Models of Renal Injury -- II. Disorders of Platelet Function in Different Renal Diseases -- Nephrotic Syndrome -- Acute Renal Failure -- Pre-eclampsia -- Uraemia -- Dialysis -- 7 Haemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A Review -- Aetiology -- Pathology -- Pathogenesis -- Haemostatic Changes in Haemolytic Uraemic Syndrome -- Treatment -- 8 Newer Pharmacological Agents -- Inhibition of Arachidonic Acid Pathway/Reduction of Synthesis of Thromboxane A2 -- Thromboxane Receptor Blockade -- Inhibition of Calcium Fluxes -- Elevation of Intra-Platelet Cyclic AMP Levels -- Protection of Endogenous Prostacyclin Release -- Promotion of Endogenous Prostacyclin Release -- Supplementation of Endogenous Prostacyclin -- Other Agents