Author | Burthem, John. author |
---|---|
Title | Hairy-cell Leukaemia [electronic resource] / by John Burthem, John C. Cawley |
Imprint | London : Springer London, 1996 |
Connect to | http://dx.doi.org/10.1007/978-1-4471-1017-0 |
Descript | IX, 111p. 36 illus. online resource |
1 Introduction and Historical Aspects -- 2 Clinical Aspects -- 2.1 Clinical features -- 2.2 Laboratory features -- 2.3 Prognosis: staging systems -- 3 Pathology -- 3.1 Bone marrow -- 3.2 Spleen -- 3.3 Liver -- 3.4 Lymph nodes -- 3.5 Other blood cells -- 3.6 Viruses and HCL -- 4 Diagnosis and Hairy-like Disorders -- 4.1 The diagnosis of typical HCL -- 4.2 Diagnosis when few abnormal cells are present -- 4.3 Diagnosis of HCL in the presence of atypical clinical or pathological features -- 4.4 Variant forms of HCL and closely related conditions -- 4.5 Atypical and rare presentations -- 5 Treatment: Mechanisms -- 5.1 Mechanism of action of splenectomy -- 5.2 The mechanism of action of ?IFN -- 5.3 Mechanism of action of the purine analogue drugs -- 6 Treatment: Practical Considerations -- 6.1 When should treatment be commenced? -- 6.2 Splenectomy -- 6.3 Interferon -- 6.4 Purine analogue drugs: DCF, CDA and fludarabine -- 6.5 The use of colony-stimulating factors in HCL -- 6.6 Overview of therapeutic options -- 6.7 Treatment after failure of primary treatment option -- 6.8 Other treatment options -- 7 The Hairy Cell -- 7.1 Cytology -- 7.2 Cytochemistry -- 7.3 Cytogenetics -- 7.4 Ultrastructure -- 7.5 Nature of the malignant cell -- 7.6 Membrane, cytoskeletal organisation and signalling -- 7.7 Response to cytokines -- 7.8 Adhesion and tissue localisation -- 7.9 Cell survival and cell death -- Appendices -- Appendix A: Tartrate-resistant acid phosphatase (TRAP) -- Appendix B: CD-antigen expression by HCs -- References