Title | Retinal Degenerative Diseases and Experimental Therapy [electronic resource] / edited by Joe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail |
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Imprint | Boston, MA : Springer US, 1999 |
Connect to | http://dx.doi.org/10.1007/b102440 |
Descript | XV, 587 p. 332 illus., 8 illus. in color. online resource |
Specific Gene Defects Cause Photoreceptor Degeneration -- Evidence for Myosin VIIa-Driven Transport of Rhodopsin in the Plasma Membrane of the Photoreceptor-Connecting Cilium -- Blindness in Usher Syndrome 1B -- Different Mutations in RPE65 Are Associated with Variability in the Severity of Retinal Dystrophy -- The RPE65-Deficient Mouse as a Model for RPE65-Associated Leberโs Congenital Amaurosis and Related Disorders -- CRALBP and Inherited Retinal Degeneration -- Guanylyl Cyclase Genes and Their Role in Retinal Degeneration -- Loss of Cone and Reduction in Rod ERG Responses in the Guanylyl Cyclase-E (GC-E) Deficient Mouse -- Guanylyl Cyclase Gene is the Disease Locus in the rd Chicken -- Leberโs Congenital Amaurosis -- Retinal Degeneration is Accelerated when a Mutant Rhodopsin Transgene is Expressed on a Haploid or Null Rhodopsin Background -- Rhodopsin C-Terminal Sequence Qvs(A)Pa Directs Its Sorting To The Ros In Retinal Photoreceptors -- The Cytoplasmic Tail of Rhodopsin Acts as a Sorting Signal in Polarized Photoreceptors and MDCK Cells -- A Homozygous 1-Base Pair Deletion (1147dela) in the Arrestin Gene in Autosomal Recessive Retinitis Pigmentosa -- mRNA Analysis of Oguchi Patients with the Frequent 1147delA Mutation in the Arrestin Gene -- Mutation Spectrum in the Rep-1 Gene of Japanese Choroideremia Patients -- Phenotype-Genotype Correlations in Retinal Degenerations Caused by Abcr gene Mutations -- Autosomal Dominant Macular Degeneration Localized to Chromosome 6q by Linkage Analysis -- The Gene Product of IMPG1 is the Glycoprotein SPACR, not an IPM Proteoglycan -- Bardet-Biedl Syndrome -- Genetic Mapping and Evaluation of PDE6A in 49 Spanish Families with Autosomal Recessive Retinitis Pigmentosa -- Grading Device for Light Perception with Retinitis Pigmentosa -- Blue Cone Monochromacy -- The Peripherin/rds Gene -- Autosomal Dominant Retinitis Pigmentosa and Hyperopia -- Intraocular Pressure in Tapetoretinal Degenerations -- Gene Therapy for Photoreceptor Rescue -- Ribozymes Directed Against Messenger RNAs Associated With Autosomal Dominant Retinitis Pigmentosa -- Ribozyme-Mediated Gene Therapy for Autosomal Dominant Retinal Degeneration -- Targeting Mรผller Cells for Gene Therapy -- The Involvement of Light in Retinal Degeneration -- Dark Adaptation is Impaired in Diabetics before Photopic Visual Losses Can be Seen -- Age and Monocular Enucleation as Potential Determinants of Light Damage in the Mouse Retina -- Ultraviolet Light Damage and Reversal by Retinoic Acid in Juvenile Goldfish Retina -- A Comparison of Light-Induced Rod Degeneration in Two Teleost Models -- Regulation of Light Absorption in the Pigmented Rat Retina -- An Uncoupling Effect of Reactive Oxygen Species on the Retinal Horizontal Cells -- Animal Models with Photoreceptor Degeneration -- Animal Model for Retinitis Pigmentosa -- Development Of Rat Models For Choroidal Neovascularisation (CNV) -- Identification of Degeneration-Specific Genes in the Rcs Rat Retina By Subtractive Hybridization Techniques -- Analysis of Field Potentials and Spike Patterns Evoked by Local Electrical Stimulation of the Chicken Retina -- Molecular and Cell Biological Studies -- Antisense Inactivation of Rds/Peripherin in Xenopus Laevis Embryonic Retinal Cultures -- Phosducin-Like Protein 1 (Phlp1) and Phosducin-Like Orphan Protein 1 (Phlop1) -- Organization of The Interphotoreceptor Matrix -- Diverse Localization of Cyclic Nucleotide Gated Channels in the Outer Segments of Rods and Cones -- Retinal Prosthesis as a Replacement for Photoreceptors -- Development of an Epiretinal Electronic Visual Prosthesis -- Response Characteristics of Subretinal Microphotodiode-Based Implant-Mediated Cortical Potentials -- Electrical Stimulation of the Human Retina -- Goals,Concepts,and Current State of the Retina Implant Project -- Are Subretinal Microphotodiodes Suitable as a Replacement For Degenerated Photoreceptors? -- Neuroprotective Agents Romote Photoreceptor Survival -- Rods Produce a Diffusible Factor Promoting Cone Photoreceptor Survival In Vivo and in Vitro -- Pigment Epithelium-Derived Factor (PEDF) in the Retina -- Retinal Neurons in Primary Cell Culture -- Melatonin Receptor Blockers Enhance Photoreceptor Survival and Function in Light Damaged Rat Retina -- Transplantation Studies -- IRIS Pigment Epithelial Cell Transplantation in Monkey Eyes -- The Retinal Pigment Epithelial Cell Differentiation and Cell Marker Expression Following Cryopreservation at -80ยฐC and under Liquid Nitrogen at -196ยฐC